Endothelial nitric oxide synthase Glu298Asp gene polymorphism influences body composition and biochemical parameters but not the nitric oxide response to eccentric resistance exercise in elderly obese women

Summary Both endothelial nitric oxide synthase (eNOS) gene polymorphism and nitric oxide (NO) are involved in important cardiovascular, muscular and inflammatory physiological mechanisms during ageing and response to exercise. The aim of this study was to investigate the NO kinetic response followin...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2016-11, Vol.36 (6), p.482-489
Main Authors: Teixeira, Tatiane Gomes, Tibana, Ramires Alsamir, Nascimento, Dahan da Cunha, de Sousa, Nuno Manuel Frade, de Souza, Vinicius Carolino, Vieira, Denis César Leite, Nóbrega, Otávio de Toledo, de Almeida, Jeeser Alves, Navalta, James, Prestes, Jonato
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
ageing
Biomarkers - blood
Body Composition - genetics
Body Mass Index
eccentric training
Exercise
Female
Gene Frequency
Genetic Association Studies
genetics
Heterozygote
Homozygote
Humans
Kinetics
Lipoproteins, VLDL - blood
Middle Aged
Muscle Strength
Nitric Oxide - metabolism
Nitric Oxide Synthase Type III - genetics
Nitric Oxide Synthase Type III - metabolism
obesity
Obesity - enzymology
Obesity - epidemiology
Obesity - genetics
Obesity - physiopathology
Phenotype
Polymorphism, Genetic
Prevalence
Resistance Training
Risk Factors
Sex Factors
strength training
Triglycerides - blood
Urea - blood
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Summary:Summary Both endothelial nitric oxide synthase (eNOS) gene polymorphism and nitric oxide (NO) are involved in important cardiovascular, muscular and inflammatory physiological mechanisms during ageing and response to exercise. The aim of this study was to investigate the NO kinetic response following an acute eccentric resistance exercise (ERE) session and the possible effect of the Glu298Asp eNOS gene polymorphism in elderly obese women. Eighty‐seven women (age 69·4 ± 6·1 years, body weight 74·9 ± 12·7 kg, height 151·9 ± 6·0 cm and BMI 32·5 ± 5·7 kg m−2) completed seven sets of ten eccentric repetitions at 110% of the ten repetitions maximum (10RM). NO concentrations remained elevated up to 48 h following the acute ERE session as compared with baseline, for GG and GT/TT groups (P
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12255