Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

Highlights • Vulnerable neurodevelopmental windows exist during the life span. • Adverse events during these times include altered gut microbiota. • Increased knowledge about parallel colonization events and brain development is required. • This is essential from a preventative, diagnostic and thera...

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Bibliographic Details
Published in:Neuroscience 2017-02, Vol.342, p.37-54
Main Authors: O’Mahony, S.M, Clarke, G, Dinan, T.G, Cryan, J.F
Format: Article
Language:English
Subjects:
Animals
Brain - growth & development
Brain - physiopathology
brain development
brain–gut axis
early-life
Female
Gastrointestinal Microbiome - physiology
Humans
microbiota
Neurology
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
stress
Stress, Psychological - physiopathology
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Summary:Highlights • Vulnerable neurodevelopmental windows exist during the life span. • Adverse events during these times include altered gut microbiota. • Increased knowledge about parallel colonization events and brain development is required. • This is essential from a preventative, diagnostic and therapeutic perspective.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.09.068