Adaptive Immune Responses of Patients with Asthma to the Attachment (G) Glycoprotein of Respiratory Syncytial Virus

A history of acute bronchiolitis in infancy caused by respiratory syncytial virus is a risk factor for recurrent wheezing in early childhood. Because the attachment (G) protein sensitizes mice for pulmonary eosinophilia and because Th2 cells are central in the pathogenesis of asthma, plasma and peri...

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Bibliographic Details
Published in:	The Journal of infectious diseases 2001-12, Vol.184 (12), p.1589-1593
Main Authors:	Hancock, Gerald E., Scheuer, Catherine A., Sierzega, Renata, Pryharski, Karin S., McBride, John T., Miller Watelet, Luc F., Tebbey, Paul W., Smith, Jason D.
Format:	Article
Language:	eng
Subjects:	Asthma Biological and medical sciences Bronchiolitis Concise Communication Cytokines Fundamental and applied biological sciences. Psychology glycoprotein G Human respiratory syncytial virus Human viral diseases Infectious diseases Medical sciences Microbiology Pulmonary eosinophilia Respiratory syncytial virus Respiratory syncytial viruses Secretion T lymphocytes Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Viruses Wheezing
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Summary:	A history of acute bronchiolitis in infancy caused by respiratory syncytial virus is a risk factor for recurrent wheezing in early childhood. Because the attachment (G) protein sensitizes mice for pulmonary eosinophilia and because Th2 cells are central in the pathogenesis of asthma, plasma and peripheral blood mononuclear cells (PBMC) from donors with asthma and from healthy donors were evaluated for anti–G protein responses. A significant trend connecting severity of asthma with anti–G protein IgG1 and IgG2 titers was observed. The correlation between anti–F protein IgG3 titers and asthma severity approached significance. Peptide mapping studies revealed that more positive recall responses (interferon-γ and interleukin-10 secretion) occurred after PBMC from donors with asthma were stimulated with peptides representing the nonglycosylated domain of G protein. The same peptides elicited more positive recall responses (proliferation and interferon-γ secretion) in the PBMC of healthy donors. These data suggest that a mechanism may exist whereby adaptive immune responses against G protein contribute to wheezing
ISSN:	0022-1899 1537-6613