Long-term intake of white tea prevents oxidative damage caused by adriamycin in kidney of rats

BACKGROUND White tea infusion (Camelia sinensis) has antioxidants properties. The infusion contains polyphenols that have been proposed to induce antioxidant response element (ARE) response via nuclear factor E2‐related factor 2 (NRF2). Adriamycin (ADR) has antitumour properties and oxidative effect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the science of food and agriculture 2016-07, Vol.96 (9), p.3079-3087
Main Authors: Espinosa, Cristóbal, López-Jiménez, José A, Pérez-Llamas, Francisca, Guardiola, Francisco A, Esteban, Maria A, Arnao, Marino B, Zamora, Salvador
Format: Article
Language:English
Subjects:
adriamycin
Animals
Antibiotics, Antineoplastic - adverse effects
Antioxidant Response Elements
Antioxidants
Antioxidants - administration & dosage
Antioxidants - isolation & purification
Antioxidants - therapeutic use
ARE response
Camellia sinensis - chemistry
Camellia sinensis - growth & development
Doxorubicin - adverse effects
Female
Food Handling
Freeze Drying
Gene expression
Gene Expression Regulation
Genes
Intakes
kidney
Kidney - drug effects
Kidney - metabolism
Kidney - physiopathology
Kidneys
Male
NF-E2-Related Factor 1 - agonists
NF-E2-Related Factor 1 - antagonists & inhibitors
NF-E2-Related Factor 1 - genetics
NF-E2-Related Factor 1 - metabolism
Nrf2
Oxidation-Reduction
Oxidative stress
Oxidative Stress - drug effects
Oxidoreductases - antagonists & inhibitors
Oxidoreductases - chemistry
Oxidoreductases - genetics
Oxidoreductases - metabolism
Plant Extracts - administration & dosage
Plant Extracts - isolation & purification
Plant Extracts - therapeutic use
Plant Leaves - chemistry
Plant Leaves - growth & development
Plant Shoots - chemistry
Plant Shoots - growth & development
Polyphenols
Rats, Sprague-Dawley
Renal Insufficiency - chemically induced
Renal Insufficiency - metabolism
Renal Insufficiency - physiopathology
Renal Insufficiency - prevention & control
Rodents
Sod
Stresses
Tea
Tea - chemistry
white tea
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND White tea infusion (Camelia sinensis) has antioxidants properties. The infusion contains polyphenols that have been proposed to induce antioxidant response element (ARE) response via nuclear factor E2‐related factor 2 (NRF2). Adriamycin (ADR) has antitumour properties and oxidative effects. Oxidative stress is related to a variety of kidney diseases. Prevention of the oxidative stress through long‐term intake of white tea and the study of the molecular mechanisms involved in protection could be of great interest. Rats were given distilled water, 0.015 or 0.045 g of solid white tea extract kg−1 body weight for 12 months. Animals received an injection of ADR. In kidney, oxidative stress parameters were measured, the expressions of nuclear factor E2‐related factor 2 gene (Nrf2), and detoxifying and antioxidants genes were analysed, and the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) were measured. RESULTS ADR administration increased oxidative parameters and decreased the antioxidant activity; significantly increased the expression of analysed genes and the activity of CAT and SOD and decreased GR activity. The highest white tea dose protected redox status and inhibited ARE response. CONCLUSION Long‐term intake of white tea protected kidney against the oxidative stress. ADR activated the ARE response but in animals treated with the highest dose of white tea, this response was inhibited, probably for antioxidant protection. © 2015 Society of Chemical Industry
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.7483