Genetic analysis of early- versus late-stage ovarian tumors

In the United States, ovarian cancer is the fourth most common cause of cancer-related deaths among women. The most important prognostic factor for this cancer is tumor stage, or extent of disease at diagnosis. Although women with low-stage tumors have a relatively good prognosis, most women diagnos...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2001-08, Vol.61 (15), p.5895-5904
Main Authors: SHRIDHAR, Viji, LEE, John, KEENEY, Gary, ROCHE, Patrick, CLIBY, William, LU, Karen, SCHMANDT, Rosemarie, MILLS, Gordon B, BAST, Robert C, JAMES, C. David, COUCH, Fergus J, HARTMANN, Lynn C, PANDITA, Ajay, LILLIE, Jim, SMITH, David I, ITURRIA, Steve, AVULA, Rajeswari, STAUB, Julie, MORRISSEY, Mike, CALHOUN, Eric, AMI SEN, KALLI, Kimberly
Format: Article
Language:English
Subjects:
Biological and medical sciences
Disease Progression
Female
Female genital diseases
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Neoplasm Staging
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Tumors
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Summary:In the United States, ovarian cancer is the fourth most common cause of cancer-related deaths among women. The most important prognostic factor for this cancer is tumor stage, or extent of disease at diagnosis. Although women with low-stage tumors have a relatively good prognosis, most women diagnosed with late-stage disease eventually succumb to their cancer. In an attempt to understand early events in ovarian carcinogenesis, and to explore steps in its progression, we have applied multiple molecular genetic techniques to the analysis of 21 early-stage (stage I/II) and 17 advanced-stage (stage III/IV) ovarian tumors. These techniques included expression profiling with cDNA microarrays containing approximately 18,000 expressed sequences, and comparative genomic hybridization to address the chromosomal locations of copy number gains as well as losses. Results from the analysis indicate that early-stage ovarian cancers exhibit profound alterations in gene expression, many of which are similar to those identified in late-stage tumors. However, differences observed at the genomic level suggest differences between the early- and late-stage tumors and provide support for a progression model for ovarian cancer development.
ISSN:0008-5472
1538-7445