Efficacy of Fostera® PRRS modified live virus (MLV) vaccination strategy against a Thai highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection

Recently, the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) (HP-PRRSV) belonging to lineage 8 causes severe symptom with high morbidity and high mortality rates to the Asian pig industry. A recent study showed that pigs immunized with Fostera® PRRS modified li...

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Bibliographic Details
Published in:Tropical animal health and production 2016-10, Vol.48 (7), p.1351-1359
Main Authors: Charoenchanikran, Ponlakrit, Kedkovid, Roongtham, Sirisereewan, Chaitawat, Woonwong, Yonlayong, Arunorat, Jirapat, Sitthichareonchai, Panchan, Sopipan, Natthawan, Jittimanee, Suphattra, Kesdangsakonwut, Sawang, Thanawongnuwech, Roongroje
Format: Article
Language:English
Subjects:
Animal diseases
Animals
Animals, Newborn
Antibodies, Viral - blood
Biomedical and Life Sciences
Experiments
Hogs
Immunization
Infections
Life Sciences
Lungs
Male
Morbidity
Porcine Reproductive and Respiratory Syndrome - mortality
Porcine Reproductive and Respiratory Syndrome - prevention & control
Porcine respiratory and reproductive syndrome virus - immunology
Porcine respiratory and reproductive syndrome virus - pathogenicity
Regular Articles
Respiratory diseases
Survival
Survival Analysis
Swine
Thailand
Tropical Climate
Vaccination
Vaccination - veterinary
Vaccines
Vaccines, Attenuated - immunology
Veterinary Medicine/Veterinary Science
Viral diseases
Viral Vaccines - immunology
Viruses
Weaning
Zoology
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Summary:Recently, the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) (HP-PRRSV) belonging to lineage 8 causes severe symptom with high morbidity and high mortality rates to the Asian pig industry. A recent study showed that pigs immunized with Fostera® PRRS modified live virus (MLV) of lineage 8 could provide a degree of protection against a Vietnamese HP-PRRSV infection. It should be noted that PRRSV commonly found after weaning causes porcine respiratory disease complex (PRDC). Vaccination strategy should be evaluated in each farm scenario. Eighty-one PRRSV-free piglets obtained from a PRRS-free herd were divided into two experiments with the major difference of infection timing after vaccination, 42 days in experiment 1 ( n  = 42) and 28 days in experiment 2 ( n  = 39). Each experiment had similar protocol containing three groups including a negative control, unvaccinated challenged, and vaccinated challenged groups. Pigs in vaccination groups were immunized with Fostera® PRRS MLV vaccine at 3 weeks of age. Then, unvaccinated challenged and vaccinated challenged groups were intranasally inoculated with a Thai HP-PRRSV (10PL01). Vaccinated challenged pigs showed significantly lower levels of mean rectal temperatures, clinical severity, lung lesion scores, and viral titers in serum and lung tissue compared to the unvaccinated challenged pigs ( p  
ISSN:0049-4747
1573-7438
DOI:10.1007/s11250-016-1099-1