Low performance of bleeding risk models in the very elderly with atrial fibrillation using vitamin K antagonists

Essentials Under‐treatment of oral anticoagulation in the elderly with atrial fibrillation is common. As bleeding prediction is challenging, we compared HAS‐BLED, ATRIA and HEMORR2HAGES. All three were associated with major bleeding in the elderly, but with poor predictive abilities. Future studies...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2016-09, Vol.14 (9), p.1715-1724
Main Authors: Jaspers Focks, J., Vugt, S. P. G., Albers‐Akkers, M. T. H., Lamfers, E. J. P., Bloem‐de Vries, L. M., Verheugt, F. W. A., Brouwer, M. A.
Format: Article
Language:English
Subjects:
Administration, Oral
Aged, 80 and over
Anticoagulants - therapeutic use
atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - diagnosis
Calibration
Cardiac arrhythmia
Female
Follow-Up Studies
Health risk assessment
hemorrhage
Hemorrhage - complications
Hemorrhage - diagnosis
Humans
Male
Netherlands
Prospective Studies
Registries
risk assessment
Risk Factors
ROC Curve
stroke
Vitamin K - antagonists & inhibitors
vitamin K antagonists
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Essentials Under‐treatment of oral anticoagulation in the elderly with atrial fibrillation is common. As bleeding prediction is challenging, we compared HAS‐BLED, ATRIA and HEMORR2HAGES. All three were associated with major bleeding in the elderly, but with poor predictive abilities. Future studies with focus on elderly‐specific risk factors for bleeding are warranted. Summary Background Anticipated bleeding complications contribute to underuse of oral anticoagulants, especially in elderly patients with atrial fibrillation (AF). Bleeding risk models could provide guidance; however, these were developed in the general AF population. Objective To study and compare the performance of the HAS‐BLED, ATRIA and HEMORR2HAGES for major bleeding in very elderly AF patients. Methods Subjects were a random sample (N = 1157) of AF patients ≥ 80 years using a vitamin‐K antagonist with prospective clinical follow‐up from 2011 to 2014. The primary outcome was major bleeding (International Society on Thrombosis and Haemostasis criteria). Results Patients aged 84 years (median; 25th–75th 82–87) were classified as low risk by HAS‐BLED (25.2%), ATRIA (59.6%) and HEMORR2HAGES (23.3%). Three‐year rates of major, clinically relevant and any bleeding were 6.7%, 28.3% and 42.3%, respectively. We observed a statistically significant association for all models with major bleeding, but discriminatory abilities were rather poor (C‐statistics < 0.60) without clear superiority for any of the three. Only two (anemia and antiplatelet therapy) of the various classical risk factors were associated with bleeding. An estimated risk–benefit profile indicated a favorable trade‐off for oral anticoagulation in this specific cohort (number needed to treat, 22; number needed to harm, 91). Conclusions In this large prospective cohort of very elderly AF patients, the currently used bleeding risk scores were all associated with major bleeding, but with poor predictive abilities. Use of the ATRIA model may inadvertently result in less attention being paid to modifiable risk factors in this particular population. In light of the issues of under‐treatment and the suggested favorable risk–benefit profile, future models with incorporation of elderly‐specific risk factors may provide more guidance in this growing population of AF patients.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.13361