Two cases of thrombocytopenic purpura at onset of Zika virus infection

Abstract We report here two cases of thrombocytopenic purpura at onset of Zika virus infection. A 26-year-old woman and a 21-year-old man had thrombocytopenia above 5 × 109 platelets/L. Hemorrhagic symptoms were mucosal and subcutaneous bleeding and gross hematuria and they reported episode of conju...

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Bibliographic Details
Published in:Journal of clinical virology 2016-10, Vol.83, p.61-62
Main Authors: Chraïbi, Samy, Najioullah, Fatiha, Bourdin, Carole, Pegliasco, Jean, Deligny, Christophe, Résière, Dabor, Meniane, Jean-Côme
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Female
Humans
Infectious Disease
Male
Purpura, Thrombocytopenic - complications
Purpura, Thrombocytopenic - diagnosis
Thrombocytopenia
Young Adult
Zika
Zika Virus
Zika Virus Infection - complications
Zika Virus Infection - diagnosis
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Summary:Abstract We report here two cases of thrombocytopenic purpura at onset of Zika virus infection. A 26-year-old woman and a 21-year-old man had thrombocytopenia above 5 × 109 platelets/L. Hemorrhagic symptoms were mucosal and subcutaneous bleeding and gross hematuria and they reported episode of conjunctivitis. In both cases blood and bone marrow analysis suggested thrombocytopenic purpura, blood PCR tests for Dengue (DENV), Chikungunya (CHIKV) and Zika virus (ZIKV) were negative. In both cases urinary PCR for ZIKV was positive, Prednisolone yielded early remission. Only three similar cases have been reported so far. In the Caribbean, DENV is also epidemic and responsible for severe thrombocytopenia. Coinfections can occur. Our report underlines the need to include a ZIKV assay in the diagnostic work-up of thrombocytopenic purpura in epidemic areas.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2016.08.299