Bone morphogenetic protein 2 / SMAD signalling in human ligamentocytes of degenerated and aged anterior cruciate ligaments

Abstract Objective Anterior cruciate ligament (ACL) degeneration leads to knee instability and favours osteoarthritis (OA) progression. During ageing the growth factor sensitivity of ligaments changes but nothing is known about BMP2-signalling and -sensitivity in degenerated ACLs. This study address...

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2016-10, Vol.24 (10), p.1816-1825
Main Authors: Ruschke, Karen, Meier, Carola, Ullah, Mujib, Michaela Krebs, Anna-Catharina, Silberreis, Kim, Kohl, Benjamin, Knaus, Petra, Jagielski, Michal, Arens, Stephan, Schulze-Tanzil, Gundula, VMD
Format: Article
Language:English
Subjects:
Ageing
Anterior Cruciate Ligament
Anterior cruciate ligament degeneration
BMP2 signalling
Bone Morphogenetic Protein 2
Chondrogenesis
Female
Fibroblasts
Humans
Ligament fibroblasts
Male
Middle Aged
Osteoarthritis
Phospho SMAD
Rheumatology
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Summary:Abstract Objective Anterior cruciate ligament (ACL) degeneration leads to knee instability and favours osteoarthritis (OA) progression. During ageing the growth factor sensitivity of ligaments changes but nothing is known about BMP2-signalling and -sensitivity in degenerated ACLs. This study addressed the question whether a dysregulated BMP2 signalling might contribute to age- and OA-dependent ACL degeneration. Method ACL samples from patients with/without OA of different ages (
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2016.05.014