Novel Scoring Criteria for the Evaluation of Ocular Graft-versus-Host Disease in a Preclinical Allogeneic Hematopoietic Stem Cell Transplantation Animal Model

Highlights • Employing an MHC-matched, minor transplantation antigen–mismatched allogeneic model of matched unrelated donor, we developed clinical scoring criterion identifying degrees of ocular pathology at both the ocular surface and adnexa • The association of these clinical changes with the deve...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2016-10, Vol.22 (10), p.1765-1772
Main Authors: Perez, Victor L, Barsam, Alexander, Duffort, Stephanie, Urbieta, Maitee, Barreras, Henry, Lightbourn, Casey, Levy, Robert B
Format: Article
Language:English
Subjects:
Allogeneic hematopoietic stem cell transplantation
Animals
Conjunctivitis
Dry Eye Syndromes
Eye Diseases - diagnosis
Eye Diseases - etiology
Eyelid Diseases
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Graft vs Host Disease - pathology
Graft-versus-host disease (GVHD)
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Inflammation
Lacrimal gland
Mice
Models, Animal
Ocular adenexa
Ocular GVHT
Ocular scoring
Severity of Illness Index
Transplantation, Homologous
Unrelated Donors
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Summary:Highlights • Employing an MHC-matched, minor transplantation antigen–mismatched allogeneic model of matched unrelated donor, we developed clinical scoring criterion identifying degrees of ocular pathology at both the ocular surface and adnexa • The association of these clinical changes with the development of immune responses around the ocular adnexa is monitored in real time • We report, for the first time, that these clinical and immune responses occur not only on the ocular surface, but they also heavily involve the lid margin region • Studies facilitate a standardized analysis of the immunologic and pathologic findings in the eye that occurs in animal models of ocular graft-versus-host disease
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2016.07.012