Fertility of patients with polycystic ovary syndrome undergoing in vitro fertilization by age

Abstract Objective To evaluate outcomes of in vitro fertilization (IVF) among patients with polycystic ovary syndrome (PCOS) by age. Methods In a retrospective study, data were retrieved for patients with PCOS (Rotterdam 2003 criteria) and individuals with tubal factor infertility who underwent IVF...

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Published in:International journal of gynecology and obstetrics 2016-10, Vol.135 (1), p.91-95
Main Authors: Hwang, Yu-Im, Cha, Sun-Wha, Song, In-Ok, Yang, Kwang-Moon, Min, Eung-Gi, Kim, Hye-Ok
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Birth Rate
Embryo Transfer
Female
Fertility
Fertilization in Vitro
Humans
In vitro fertilization
Infertility, Female - therapy
Obstetrics and Gynecology
Oocyte Retrieval
Ovulation Induction
Polycystic ovary syndrome
Polycystic Ovary Syndrome - therapy
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Republic of Korea
Retrospective Studies
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Summary:Abstract Objective To evaluate outcomes of in vitro fertilization (IVF) among patients with polycystic ovary syndrome (PCOS) by age. Methods In a retrospective study, data were retrieved for patients with PCOS (Rotterdam 2003 criteria) and individuals with tubal factor infertility who underwent IVF at a center in Seoul, South Korea, between January 2003 and August 2012. IVF outcomes were compared by age group (A: 30–32 years; B: 33–35 years; C: 36–38 years; D: 39–41 years). Results The analysis included 307 women with PCOS and 364 with tubal factor infertility. There was a significant difference between women with PCOS and those with tubal infertility factor in the live birth rate in group B (41.3% vs 28.6%, P = 0.038) and in group C (40.4% vs 15.1%, P = 0.002). Among women with PCOS, no significant differences in number of retrieved oocytes were observed between the age groups (18.8 ± 9.6, 19.1 ± 10.0, 17.7 ± 7.5, and 17.0 ± 13.8). However, the clinical pregnancy rate was significantly lower in group D than in group C (47.2% vs 18.8%, P = 0.042). Conclusion Fertility in patients with PCOS was maintained until age 38 years using IVF. Thereafter, the pregnancy rate decreased, although the number of oocytes retrieved by IVF remained stable.
ISSN:0020-7292
1879-3479
DOI:10.1016/j.ijgo.2016.03.033