On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor

Antidepressant drugs are reported to be used as co-analgesics in clinical management of migraine and neuropathic pain. The mechanism through which they alleviate pain remains unknown. The present study explores the possible mechanism of a selective serotonin reuptake inhibitor (SSRI) fluoxetine-indu...

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Bibliographic Details
Published in:Brain research 2001-10, Vol.915 (2), p.218-226
Main Authors: Singh, Vijay Pal, Jain, Naveen K, Kulkarni, S.K
Format: Article
Language:English
Subjects:
Abdominal constriction
Analgesics - administration & dosage
Analgesics - pharmacology
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Synergism
Fluoxetine
Fluoxetine - administration & dosage
Fluoxetine - pharmacology
Hot Temperature - adverse effects
Humans
Injections, Intraperitoneal
Injections, Intraventricular
Male
Medical sciences
Mice
Morphine - administration & dosage
Morphine - antagonists & inhibitors
Naloxone
Neuropharmacology
Opioid
Pain Measurement - drug effects
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
Selective serotonin reuptake inhibitor
selective serotonin reuptake inhibitors
Serotonin Uptake Inhibitors - administration & dosage
Serotonin Uptake Inhibitors - pharmacology
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Summary:Antidepressant drugs are reported to be used as co-analgesics in clinical management of migraine and neuropathic pain. The mechanism through which they alleviate pain remains unknown. The present study explores the possible mechanism of a selective serotonin reuptake inhibitor (SSRI) fluoxetine-induced antinociception in animals. Acetic acid-induced writhing, hot plate and tail-flick test were used to assess fluoxetine-induced antinociception. Fluoxetine (5–20 mg kg −1, i.p.) produced a significant and dose-dependent antinociceptive effect against acetic acid-induced writhing in mice. Fluoxetine (20 mg kg −1) also exhibited antinociceptive effect in tail flick as well as hot plate assays. Further, i.c.v. administration of fluoxetine showed significant antinociception against writhing test in rats. However, fluoxetine (1 μg/10 μl/rat, i.c.v.) did not exhibit any antinociceptive effect in serotonin-depleted animals. Further, pindolol (10 mg kg −1, i.p.) enhanced fluoxetine-induced antinociceptive effect. The antinociceptive effect of fluoxetine was sensitive to blockade by naloxone (5 mg kg −1, i.p.) and naltrexone (5 mg kg −1, i.p.). These data suggest that fluoxetine-induced antinociception involves both central opioid and the serotoninergic pathways.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02854-2