Risk factors and associated diseases among preterm infants with isolated lenticulostriate vasculopathy

To determine the prevalence, risk factors and diseases associated with isolated lenticulostriate vasculopathy (LSV) among preterm infants. Medical records of 84 preterm infants (gestational age (GA) 25 to 34 weeks) with isolated LSV in a case-control retrospective study over a period of 6.5 years we...

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Bibliographic Details
Published in:Journal of perinatology 2016-09, Vol.36 (9), p.775-778
Main Authors: Maayan-Metzger, A, Leibovitch, L, Schushan-Eisen, I, Soudack, M, Strauss, T
Format: Article
Language:English
Subjects:
Basal Ganglia Cerebrovascular Disease - complications
Basal Ganglia Cerebrovascular Disease - diagnostic imaging
Birth Weight
Case-Control Studies
Cerebrovascular disease
Complications
Cytomegalovirus
Development and progression
Diabetes
Diseases
Dysplasia
Echoencephalography
Female
Gestational Age
Health aspects
Health risks
Hospitalization
Humans
Infant
Infant, Extremely Premature
Infant, Newborn
Infants
Infants (Newborn)
Infants (Premature)
Israel
Length of Stay
Logistic Models
Lung diseases
Male
Mechanical ventilation
Medical records
Methods
Morbidity
Neonatal care
Neonates
Newborn babies
Pediatric research
Premature babies
Premature infants
Preventive medicine
Respiration, Artificial
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - complications
Respiratory Distress Syndrome, Newborn - therapy
Retrospective Studies
Risk analysis
Risk Factors
Ultrasonic imaging
Vascular diseases
Vasculitis
Ventilators
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Summary:To determine the prevalence, risk factors and diseases associated with isolated lenticulostriate vasculopathy (LSV) among preterm infants. Medical records of 84 preterm infants (gestational age (GA) 25 to 34 weeks) with isolated LSV in a case-control retrospective study over a period of 6.5 years were reviewed and compared with matched control infants. LSV was defined as 'early' if it was documented in head ultrasound (HUS) before or on the fifth day of life and 'late' if it was not present in the first HUS and recorded later during neonatal hospitalization. A 3.9% prevalence of LSV was recorded among preterm infants (GA⩽34 weeks). Study and control groups were similar for all maternal parameters, neonatal outcomes and length of hospitalization. Infants with late LSV had more neonatal complications than control infants and were born with younger GA and lower birth weight in comparison to infants with early LSV. More infants with late LSV needed mechanical ventilation, were diagnosed with bronchopulmonary dysplasia and were hospitalized longer in comparison to infants with early LSV. Urine cytomegalovirus was negative in the entire study group. No risk factors or specific associated morbidities were identified among preterm infants with early isolated LSV. Infants with late isolated LSV were younger and had overall increased associated morbidities. Long-term outcome studies are needed to determine LSV impact.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2016.67