Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery

Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long‐lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injecti...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2015-09, Vol.27 (34), p.5002-5008
Main Authors: Pakulska, Malgosia M., Vulic, Katarina, Tam, Roger Y., Shoichet, Molly S.
Format: Article
Language:English
Subjects:
Biocompatibility
Controlled release
Crosslinking
design of experiment
Design of experiments
Drug Carriers - chemistry
drug delivery
Drug delivery systems
Drug Design
Drug Liberation
Hydrogels
Hydrogels - chemistry
Lactic Acid - chemistry
Methylcellulose - chemistry
Nanoparticles - chemistry
Platforms
Polyglycolic Acid - chemistry
Proteins
rheology
spinal cord injuries
Swelling
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Summary:Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long‐lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201502767