Targeted Molecular Imaging of Cancer Cells Using MS2-Based super( 129)Xe NMR

We have synthesized targeted, selective, and highly sensitive super( 129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized super( 129)...

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Bibliographic Details
Published in:Bioconjugate chemistry 2016-08, Vol.27 (8), p.1796-1796
Main Authors: Jeong, Keunhong, Netirojjanakul, Chawita, Munch, Henrik K, Sun, Jinny, Finbloom, Joel A, Wemmer, David E, Pines, Alexander, Francis, Matthew B
Format: Article
Language:English
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Summary:We have synthesized targeted, selective, and highly sensitive super( 129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized super( 129)Xe NMR signal contrast and hyper-CEST super( 129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized super( 129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
ISSN:1043-1802