In Vivo MRI and X-Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO4 ·H2 O Nanobundles for Tracing Bone Implant and Bone Regeneration

Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-09, Vol.5 (17), p.2182-2190
Main Authors: Huang, Jing, Lv, Zhongwen, Wang, Yu, Wang, Zongliang, Gao, Tianlin, Zhang, Ning, Guo, Min, Zou, Haifeng, Zhang, Peibiao
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Bone Regeneration
Cell Line
Contrast Media - chemistry
Contrast Media - pharmacology
Durapatite - chemistry
Durapatite - pharmacology
Gadolinium - chemistry
Gadolinium - pharmacology
Magnetic Resonance Imaging
Mice
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Tomography, X-Ray Computed
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Summary:Homogeneous and monodisperse GdPO4 ·H2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO4 ·H2 O are incorporated into the composite of hydroxyapatite and poly(lactic-co-glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO4 ·H2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X-ray imaging.
ISSN:2192-2659
DOI:10.1002/adhm.201600249