Urinary tract infections in children with prenatal hydronephrosis: A risk assessment from the Society for Fetal Urology Hydronephrosis Registry

Summary Introduction Risk factors for urinary tract infection (UTI) in children with prenatal hydronephrosis (PNH) are not clearly defined. Our study aim was to describe incidence and identify factors associated with UTI among a cohort of children diagnosed with PNH. Material and methods Patients wi...

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Bibliographic Details
Published in:Journal of pediatric urology 2016-08, Vol.12 (4), p.261.e1-261.e7
Main Authors: Zee, Rebecca S, Herbst, Katherine W, Kim, Christina, McKenna, Patrick H, Bently, Tom, Cooper, Christopher S, Herndon, C.D. Anthony
Format: Article
Language:English
Subjects:
Antibiotics
Female
Fetal Diseases
Humans
Hydronephrosis
Hydronephrosis - complications
Hydronephrosis - embryology
Incidence
Infant, Newborn
Male
Pediatrics
Registries
Risk Assessment
Risk Factors
Societies, Medical
Urinary tract infection
Urinary Tract Infections - epidemiology
Urinary Tract Infections - etiology
Urology
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Summary:Summary Introduction Risk factors for urinary tract infection (UTI) in children with prenatal hydronephrosis (PNH) are not clearly defined. Our study aim was to describe incidence and identify factors associated with UTI among a cohort of children diagnosed with PNH. Material and methods Patients with confirmed PNH from four medical centers were prospectively enrolled in the Society for Fetal Urology (SFU) hydronephrosis registry between 9/2008 and 10/2015. Exclusion criteria included enrollment because of UTI, associated congenital anomalies, and less than 1-month follow-up. Univariate analysis was performed using Fisher’s Exact test or Mann-Whitney U. Probability for UTI was determined by Kaplan-Meier curve. Results Median follow-up was 12 (IQR 4-20) months in 213 patients prenatally diagnosed with hydronephrosis. The majority of the cohort was male (72%), Caucasian (77%), and 26% had high grade (SFU 3 or 4) hydronephrosis. Circumcision was performed in 116/147 (79%) with known status, 19% had vesicoureteral reflux (VUR), and 11% had ureteral dilatation. UTI developed in 8% ( n =18), 89% during their first year of life. Univariate analysis found UTI developed more frequently in females ( p
ISSN:1477-5131
1873-4898
DOI:10.1016/j.jpurol.2016.04.024