Dopamine D sub(1A) receptor function in a rodent model of tardive dyskinesia

Tardive dyskinesia develops as a common complication of long-term neuroleptic use. The emergence of such dyskinesias may reflect a shift in the balance of dopamine D sub(1) and D sub(2) receptor-mediated activity, with a relative increase in activity in the D sub(1) receptor-regulated direct striato...

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Bibliographic Details
Published in:Neuroscience 2000-11, Vol.101 (3), p.629-635
Main Authors: Van Kampen, JM, Stoessl, A J
Format: Article
Language:English
Online Access:Get full text
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Summary:Tardive dyskinesia develops as a common complication of long-term neuroleptic use. The emergence of such dyskinesias may reflect a shift in the balance of dopamine D sub(1) and D sub(2) receptor-mediated activity, with a relative increase in activity in the D sub(1) receptor-regulated direct striatonigral pathway. In rats, chronic treatment with the antipsychotic fluphenazine triggers a syndrome of vacuous chewing movements, which are attenuated by dopamine D sub(1) receptor antagonists. A similar syndrome can be seen in drug-naive animals following acute administration of selective dopamine D sub(1) receptor agonists. However, not all dopamine D sub(1) receptor agonists elicit these mouth movements. Thus, some investigators have suggested the existence of novel subtypes of the dopamine D sub(1) receptor. In these studies, we sought to clarify the role of the dopamine D sub(1A) receptor in vacuous chewing movements induced both by the selective dopamine D sub(1) receptor agonist SKF 38393, as well as by chronic neuroleptic administration, using in vivo oligonucleotide antisense to dopamine D sub(1A) receptor messenger RNA. Intrastriatal antisense treatment significantly and selectively attenuated striatal dopamine D sub(1) receptor binding, accompanied by reductions in SKF 38393- and chronic fluphenazine- induced vacuous chewing movements. These findings suggest that the dopamine D sub(1A) receptor plays an important role in the expression of vacuous chewing movements in a rodent model of tardive dyskinesia and may contribute to the pathogenesis of the human disorder. This may have important implications for the treatment of tardive dyskinesia in humans.
ISSN:0306-4522