Early severe anemia as the first sign of cystic fibrosis

Severe anemia is reported to occur rarely in patients with cystic fibrosis (CF). This study aimed to determine the factors associated with early severe anemia in infants with CF. This study included 231 infants with CF from 3 pediatric CF centers ten year period that were retrospectively reviewed in...

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Bibliographic Details
Published in:	European journal of pediatrics 2016-09, Vol.175 (9), p.1157-1163
Main Authors:	Sismanlar, Tugba, Aslan, Ayşe Tana, Köse, Mehmet, Pekcan, Sevgi, Ezgü, Fatih Süheyl, Budakoğlu, Işıl İrem, Yenicesu, İdil
Format:	Article
Language:	eng
Subjects:	Age of Onset Anemia - etiology Anemia - therapy Case-Control Studies Cystic Fibrosis - complications Cystic Fibrosis - diagnosis Female Humans Infant Infant, Newborn Male Medicine Medicine & Public Health Original Article Pediatrics Retrospective Studies
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Summary:	Severe anemia is reported to occur rarely in patients with cystic fibrosis (CF). This study aimed to determine the factors associated with early severe anemia in infants with CF. This study included 231 infants with CF from 3 pediatric CF centers ten year period that were retrospectively reviewed in terms of severe anemia as the first sign of CF. Factors that could affect anemia, such as age, pancreatic insufficiency, mutations, vitamin A and E, and albumin level were evaluated. Clinical and laboratory findings in CF patients that presented with severe anemia and no respiratory symptoms were compared to those in CF patients that did not present with severe anemia. Severe anemia as the first sign of CF was noted in 17 of 231 patients. Patient age, prolonged PT/INR and the albumin level differed significantly between the 2 groups of patients ( P
ISSN:	0340-6199 1432-1076