Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review

Metabolic syndrome is defined by a constellation of complex coexisting cardiometabolic risk factors such as hyperglycemia, dyslipidemia, inflammation, abdominal obesity, coagulopathies, and hypertension that raise the risk of diabetes mellitus and cardiovascular disease. Recently, there has been an...

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Bibliographic Details
Published in:Naunyn - Schmiedeberg's Archives of Pharmacology 2016-09, Vol.389 (9), p.931-949
Main Authors: Hassani, Faezeh Vahdati, Shirani, Kobra, Hosseinzadeh, Hossein
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - therapeutic use
Anti-Obesity Agents - adverse effects
Anti-Obesity Agents - isolation & purification
Anti-Obesity Agents - therapeutic use
Antioxidants - adverse effects
Antioxidants - isolation & purification
Antioxidants - therapeutic use
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood Glucose - drug effects
Blood Glucose - metabolism
Cardiovascular Agents - adverse effects
Cardiovascular Agents - isolation & purification
Cardiovascular Agents - therapeutic use
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Gluconeogenesis - drug effects
Humans
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - therapeutic use
Hypolipidemic Agents - adverse effects
Hypolipidemic Agents - isolation & purification
Hypolipidemic Agents - therapeutic use
Inflammation Mediators - blood
Lamiaceae
Lipids - blood
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - drug therapy
Neurosciences
Oxidative Stress - drug effects
Pharmacology/Toxicology
Phytotherapy
Plant Extracts - adverse effects
Plant Extracts - isolation & purification
Plant Extracts - therapeutic use
Plants, Medicinal
Review
Risk Factors
Rosmarinus - chemistry
Rosmarinus officinalis
Weight Gain - drug effects
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Description
Summary:Metabolic syndrome is defined by a constellation of complex coexisting cardiometabolic risk factors such as hyperglycemia, dyslipidemia, inflammation, abdominal obesity, coagulopathies, and hypertension that raise the risk of diabetes mellitus and cardiovascular disease. Recently, there has been an increasing interest in the use of herbs and natural compounds in prevention and treatment of diseases and a large number of published articles have focused on this issue. Rosmarinus officinalis L. or rosemary (Lamiaceae) is a rich source of phenolic phytochemicals having significant anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, hypotensive, anti-atherosclerotic, anti-thrombotic, hepatoprotective, and hypocholesterolemic effects. The purpose of this review is to highlight the interesting pharmacological effects of rosemary, and its active compounds, and the related mechanisms in the management of metabolic syndrome that are documented in in vitro and in vivo studies.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-016-1256-0