Hepatitis B and Schistosoma co-infection in a non-endemic area

Schistosomiasis is related to the development of liver fibrosis and portal hypertension. Chronic co-infection with HBV and Schistosoma has been associated in endemic areas with a higher risk for a more severe liver disease. However, no studies have assessed the real importance of this co-infection i...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2016-09, Vol.35 (9), p.1487-1493
Main Authors: Cuenca-Gómez, J. Á., Salas-Coronas, J., Lozano-Serrano, A. B., Vázquez-Villegas, J., Soriano-Pérez, M. J., Estévez-Escobar, M., Villarejo-Ordóñez, A., Cabezas-Fernández, M. T.
Format: Article
Language:English
Subjects:
Adult
Africa South of the Sahara
Animals
Biomedical and Life Sciences
Biomedicine
Coinfection - diagnosis
Coinfection - epidemiology
Coinfection - pathology
Disease
Emigrants and Immigrants
Female
Hepatitis B
Hepatitis B virus
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - diagnosis
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - pathology
Hepatitis C
Humans
Immigrants
Infections
Internal Medicine
Liver cirrhosis
Liver Cirrhosis - diagnosis
Liver Cirrhosis - epidemiology
Liver Cirrhosis - pathology
Male
Medical Microbiology
Observational studies
Original Article
Retrospective Studies
Schistosoma
Schistosoma mansoni
Schistosomiasis - complications
Schistosomiasis - diagnosis
Schistosomiasis - epidemiology
Schistosomiasis - pathology
Serology
Spain - epidemiology
Urine
Young Adult
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Summary:Schistosomiasis is related to the development of liver fibrosis and portal hypertension. Chronic co-infection with HBV and Schistosoma has been associated in endemic areas with a higher risk for a more severe liver disease. However, no studies have assessed the real importance of this co-infection in non-endemic regions. This is a retrospective observational study of Sub-Saharan immigrants attending between October 2004 and February 2014. Patients with chronic HBV infection with and without evidence of schistosomal infection were compared. Epidemiological, analytical, and microbiological data were analysed. Likelihood of liver fibrosis based on APRI and FIB-4 indexes was established. A total of 507 patients were included in the study, 170 (33.5 %) of them harbouring evidence of schistosome infection. No differences were found in transaminase, GGT, and ALP levels. In fibrosis tests, a higher proportion of patients with HVB and S. mansoni detection reached possible fibrosis scores (F > 2) when compared to patients without schistosomiasis: 17.4 vs 14.2 % and 4.3 % vs 4.2 % (using high sensitivity and high specificity cut-offs respectively), although differences were not statistically significant ( p  = 0.69, p  = 0.96). For possible cirrhosis (F4) score, similar results were observed: 4.3 % of co-infected patients vs 2.1 % of mono-infected ones, p  = 0.46. According to these datas, in non-endemic regions the degree of hepatic fibrosis in patients with chronic hepatitis B is not substantially modified by schistosome co-infection.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-016-2689-6