Facial Emotion Processing in Aviremic HIV-infected Adults

The emotional processing in human immunodeficiency virus-seropositive individuals (HIV+) has been scarcely studied. We included HIV+ individuals (n = 107) on antiretroviral therapy (≥2 years) who completed 6 facial processing tasks and neurocognitive testing. We compared HIV+ and healthy adult (HA)...

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Bibliographic Details
Published in:Archives of clinical neuropsychology 2016-08, Vol.31 (5), p.401-410
Main Authors: González-Baeza, A, Carvajal, F, Bayón, C, Pérez-Valero, I, Montes-Ramírez, M, Arribas, J R
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anti-Retroviral Agents - pharmacology
Anti-Retroviral Agents - therapeutic use
Cognition Disorders - etiology
Cognition Disorders - virology
Emotions - drug effects
Emotions - physiology
Facial Expression
Female
Hepatitis C virus
HIV - genetics
HIV Infections - blood
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Lentivirus
Lipopolysaccharide Receptors - blood
Male
Mental Recall - drug effects
Middle Aged
Neuropsychological Tests
Photic Stimulation
Predictive Value of Tests
Recognition (Psychology) - drug effects
Recognition (Psychology) - physiology
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Summary:The emotional processing in human immunodeficiency virus-seropositive individuals (HIV+) has been scarcely studied. We included HIV+ individuals (n = 107) on antiretroviral therapy (≥2 years) who completed 6 facial processing tasks and neurocognitive testing. We compared HIV+ and healthy adult (HA) participants (n = 40) in overall performance of each facial processing task. Multiple logistic regressions were conducted to explore predictors of poorer accuracy in those measures in which HIV+ individuals performed poorer than HA participants. We separately explored the impact of neurocognitive status, antiretroviral regimen, and hepatitis C virus (HCV) coinfection on the tasks performance. We found similar performance in overall facial emotion discrimination, recognition, and recall between HIV+ and HA participants. The HIV+ group had poorer recognition of particular negative emotions. Lower WAIS-III Vocabulary scores and active HCV predicted poorer accuracy in recognition of particular emotions. Our results suggest that permanent damage of emotion-related brain systems might persist despite long-term effective antiretroviral therapy.
ISSN:0887-6177
1873-5843
DOI:10.1093/arclin/acw023