Alanyl-glutamine supplementation regulates mTOR and ubiquitin proteasome proteolysis signaling pathways in piglets

Abstract Objective The aim of the present study was to investigate the effects of the alanyl-glutamine dipeptide (Ala-Gln) or the combination supplementation of free alanine and glutamine (Ala+Gln) on the mammalian target of rapamycin (mTOR) and ubiquitin-proteasome proteolysis (UPP) signaling pathw...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016-10, Vol.32 (10), p.1123-1131
Main Authors: Zhang, Bolin, Ph.D, Lin, Meng, M.A, Yu, Changning, M.A, Li, Jiaolong, Ph.D, Zhang, Lin, Ph.D, Zhou, Ping, Ph.D, Yang, Wenwei, M.A, Gao, Feng, Ph.D, Zhou, Guanghong, Ph.D
Format: Article
Language:English
Subjects:
Alanine - administration & dosage
Alanine Transaminase - metabolism
Alanyl-glutamine
Amino acids
Animals
Aqueous solutions
Aspartate Aminotransferases - metabolism
Dehydrogenases
Dietary Supplements
Dipeptides - administration & dosage
Enzymes
Experiments
Gastroenterology and Hepatology
Glutamate Dehydrogenase - genetics
Glutamate-Ammonia Ligase - metabolism
Glutamic Acid - metabolism
Glutaminase - genetics
Glutamine - administration & dosage
Glutamine - metabolism
Glutaminolysis
Hogs
Kinases
Liver
Liver - drug effects
Liver - metabolism
Male
Metabolism
mTOR signaling
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Musculoskeletal system
Nutrition research
Piglet
Proteasome Endopeptidase Complex - drug effects
Proteasome Endopeptidase Complex - metabolism
Protein synthesis
Proteins
Proteolysis - drug effects
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction - drug effects
Sus scrofa
TOR Serine-Threonine Kinases - metabolism
Ubiquitin-proteasome proteolysis signaling
Ubiquitins - metabolism
Weight Gain - drug effects
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Summary:Abstract Objective The aim of the present study was to investigate the effects of the alanyl-glutamine dipeptide (Ala-Gln) or the combination supplementation of free alanine and glutamine (Ala+Gln) on the mammalian target of rapamycin (mTOR) and ubiquitin-proteasome proteolysis (UPP) signaling pathways in piglets. Methods We randomly allocated 180 piglets to three treatments with three replicates of 20 piglets each, fed with diets containing 0.62% Ala, 0.5% Ala-Gln, 0.21% Ala+0.34% Gln, respectively. The duration of the experiment was 28 d. Results The results showed that Ala-Gln increased average daily gain of piglets, and decreased the ratio of feed to gain ( P  
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2016.02.023