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Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study
Background Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer o...
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Published in: | Journal of gastroenterology 2016-09, Vol.51 (9), p.891-899 |
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description | Background
Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994–2010.
Methods
The study population included all individuals aged 16 years or older living in Denmark during 1994–2010 (
n
= 7,070,142). Patients with SBC were identified through the Danish Cancer Registry. Incidence rates were calculated overall and according to the anatomical origin and morphological subtype. Patients were followed up from the date of cancer diagnosis to the date of emigration, death or the end of the study (31 December 2010).
Results
SBC was diagnosed in 1088 patients during 1994–2010. The total annual incidence of SBC was 1.10 per 100,000 [95 % confidence interval (CI) 1.04 to 1.17 per 100,000], with an annual percentage change of 1.9 % (95 % CI 0.6–3.1 %,
p
= 0.003) during the observation period. This increase was mainly explained by an increase in the occurrence of duodenal adenocarcinomas, with an annual percentage change of 7.5 % (95 % CI 4.9–10.2 %,
p
|
doi_str_mv | 10.1007/s00535-016-1171-7 |
format | article |
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Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994–2010.
Methods
The study population included all individuals aged 16 years or older living in Denmark during 1994–2010 (
n
= 7,070,142). Patients with SBC were identified through the Danish Cancer Registry. Incidence rates were calculated overall and according to the anatomical origin and morphological subtype. Patients were followed up from the date of cancer diagnosis to the date of emigration, death or the end of the study (31 December 2010).
Results
SBC was diagnosed in 1088 patients during 1994–2010. The total annual incidence of SBC was 1.10 per 100,000 [95 % confidence interval (CI) 1.04 to 1.17 per 100,000], with an annual percentage change of 1.9 % (95 % CI 0.6–3.1 %,
p
= 0.003) during the observation period. This increase was mainly explained by an increase in the occurrence of duodenal adenocarcinomas, with an annual percentage change of 7.5 % (95 % CI 4.9–10.2 %,
p
< 0.001). Further, 29 % of all SBC patients had metastatic cancer at the time of diagnosis and 32 % had one or more synchronous/metachronous cancers. All morphological subtypes were associated with poor 5-year prognoses, in particular duodenal adenocarcinomas, with a 5-year survival rate of only 16 % (95 % CI 12–22 %).
Conclusions
The incidence of SBC has increased in recent decades, mainly because of a large increase in the incidence of duodenal adenocarcinomas, which are also associated with the poorest prognosis.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-016-1171-7</identifier><identifier>PMID: 26847562</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adenocarcinoma - diagnosis ; Adenocarcinoma - epidemiology ; Adenocarcinoma - pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cancer ; Cohort Studies ; Colorectal cancer ; Colorectal Surgery ; Denmark - epidemiology ; Female ; Gastroenterology ; Genetic aspects ; Hepatology ; Humans ; Incidence ; Intestinal Neoplasms - diagnosis ; Intestinal Neoplasms - epidemiology ; Intestinal Neoplasms - pathology ; Intestine, Small - pathology ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplasms, Multiple Primary - diagnosis ; Neoplasms, Multiple Primary - epidemiology ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Second Primary - diagnosis ; Neoplasms, Second Primary - epidemiology ; Neoplasms, Second Primary - pathology ; Neuroendocrine Tumors - diagnosis ; Neuroendocrine Tumors - epidemiology ; Neuroendocrine Tumors - pathology ; Oncology, Experimental ; Original Article—Alimentary Tract ; Phenotype ; Prognosis ; Registries ; Sarcoma - diagnosis ; Sarcoma - epidemiology ; Sarcoma - pathology ; Surgical Oncology ; Survival Analysis ; Young Adult</subject><ispartof>Journal of gastroenterology, 2016-09, Vol.51 (9), p.891-899</ispartof><rights>Japanese Society of Gastroenterology 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-38c1b705296ed2c730999164cb561da84df7378b6b99419d7aca3fd209b120343</citedby><cites>FETCH-LOGICAL-c562t-38c1b705296ed2c730999164cb561da84df7378b6b99419d7aca3fd209b120343</cites><orcidid>0000-0003-3998-1160</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27937,27938</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26847562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bojesen, Rasmus Dahlin</creatorcontrib><creatorcontrib>Andersson, Mikael</creatorcontrib><creatorcontrib>Riis, Lene Buhl</creatorcontrib><creatorcontrib>Nielsen, Ole Haagen</creatorcontrib><creatorcontrib>Jess, Tine</creatorcontrib><title>Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994–2010.
Methods
The study population included all individuals aged 16 years or older living in Denmark during 1994–2010 (
n
= 7,070,142). Patients with SBC were identified through the Danish Cancer Registry. Incidence rates were calculated overall and according to the anatomical origin and morphological subtype. Patients were followed up from the date of cancer diagnosis to the date of emigration, death or the end of the study (31 December 2010).
Results
SBC was diagnosed in 1088 patients during 1994–2010. The total annual incidence of SBC was 1.10 per 100,000 [95 % confidence interval (CI) 1.04 to 1.17 per 100,000], with an annual percentage change of 1.9 % (95 % CI 0.6–3.1 %,
p
= 0.003) during the observation period. This increase was mainly explained by an increase in the occurrence of duodenal adenocarcinomas, with an annual percentage change of 7.5 % (95 % CI 4.9–10.2 %,
p
< 0.001). Further, 29 % of all SBC patients had metastatic cancer at the time of diagnosis and 32 % had one or more synchronous/metachronous cancers. All morphological subtypes were associated with poor 5-year prognoses, in particular duodenal adenocarcinomas, with a 5-year survival rate of only 16 % (95 % CI 12–22 %).
Conclusions
The incidence of SBC has increased in recent decades, mainly because of a large increase in the incidence of duodenal adenocarcinomas, which are also associated with the poorest prognosis.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal Surgery</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Genetic aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intestinal Neoplasms - diagnosis</subject><subject>Intestinal Neoplasms - epidemiology</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Intestine, Small - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary - diagnosis</subject><subject>Neoplasms, Multiple Primary - epidemiology</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Second Primary - diagnosis</subject><subject>Neoplasms, Second Primary - epidemiology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Neuroendocrine Tumors - diagnosis</subject><subject>Neuroendocrine Tumors - epidemiology</subject><subject>Neuroendocrine Tumors - pathology</subject><subject>Oncology, Experimental</subject><subject>Original Article—Alimentary Tract</subject><subject>Phenotype</subject><subject>Prognosis</subject><subject>Registries</subject><subject>Sarcoma - diagnosis</subject><subject>Sarcoma - epidemiology</subject><subject>Sarcoma - pathology</subject><subject>Surgical Oncology</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNks1u1TAQhS0EopfCA7BBltiwaFqPf-KYXVWgrVSpG1hbju2UlMQOdtLq7ngH3pAnweGWX4GEvLA8_ub4jHUQegrkEAiRR5kQwURFoK4AJFTyHtoALxWhKL2PNkRxvt7wPfQo52tCgBHRPER7tG64FDXdoHQebO98sB7H7gBP732I83byuRyxCQ7nJd30N2bAXYojzqMZBtzGWz9ga0pXwn3Ar3wYTfpwgEEp_uXTZ0qAvMQGT3FaBjP3MVStyb6IzYvbPkYPOjNk_-Ru30fv3rx-e3JWXVyenp8cX1S2OJsr1lhoJRFU1d5RKxlRSkHNbStqcKbhrpNMNm3dlkdBOWmsYZ2jRLVACeNsH73Y6U4pflx8nvXYZ-uHwQQfl6yhAVErJSn8D0qbhjVSFfT5H-h1XFIog3yjmKoFlz-pKzN43YcuzsnYVVQfS-CiYVKtDg__QpXl_NjbGHzXl_pvDbBrsCnmnHynp9SXr99qIHqNhN5FQpdI6DUSerXy7M7w0o7e_ej4noEC0B2Qy1W48umXif6p-hXavb1A</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Bojesen, Rasmus Dahlin</creator><creator>Andersson, Mikael</creator><creator>Riis, Lene Buhl</creator><creator>Nielsen, Ole Haagen</creator><creator>Jess, Tine</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3998-1160</orcidid></search><sort><creationdate>20160901</creationdate><title>Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study</title><author>Bojesen, Rasmus Dahlin ; Andersson, Mikael ; Riis, Lene Buhl ; Nielsen, Ole Haagen ; Jess, Tine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-38c1b705296ed2c730999164cb561da84df7378b6b99419d7aca3fd209b120343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal Surgery</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Genetic aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intestinal Neoplasms - diagnosis</topic><topic>Intestinal Neoplasms - epidemiology</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Intestine, Small - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary - diagnosis</topic><topic>Neoplasms, Multiple Primary - epidemiology</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Second Primary - diagnosis</topic><topic>Neoplasms, Second Primary - epidemiology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Neuroendocrine Tumors - diagnosis</topic><topic>Neuroendocrine Tumors - epidemiology</topic><topic>Neuroendocrine Tumors - pathology</topic><topic>Oncology, Experimental</topic><topic>Original Article—Alimentary Tract</topic><topic>Phenotype</topic><topic>Prognosis</topic><topic>Registries</topic><topic>Sarcoma - diagnosis</topic><topic>Sarcoma - epidemiology</topic><topic>Sarcoma - pathology</topic><topic>Surgical Oncology</topic><topic>Survival Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bojesen, Rasmus Dahlin</creatorcontrib><creatorcontrib>Andersson, Mikael</creatorcontrib><creatorcontrib>Riis, Lene Buhl</creatorcontrib><creatorcontrib>Nielsen, Ole Haagen</creatorcontrib><creatorcontrib>Jess, Tine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bojesen, Rasmus Dahlin</au><au>Andersson, Mikael</au><au>Riis, Lene Buhl</au><au>Nielsen, Ole Haagen</au><au>Jess, Tine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>51</volume><issue>9</issue><spage>891</spage><epage>899</epage><pages>891-899</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994–2010.
Methods
The study population included all individuals aged 16 years or older living in Denmark during 1994–2010 (
n
= 7,070,142). Patients with SBC were identified through the Danish Cancer Registry. Incidence rates were calculated overall and according to the anatomical origin and morphological subtype. Patients were followed up from the date of cancer diagnosis to the date of emigration, death or the end of the study (31 December 2010).
Results
SBC was diagnosed in 1088 patients during 1994–2010. The total annual incidence of SBC was 1.10 per 100,000 [95 % confidence interval (CI) 1.04 to 1.17 per 100,000], with an annual percentage change of 1.9 % (95 % CI 0.6–3.1 %,
p
= 0.003) during the observation period. This increase was mainly explained by an increase in the occurrence of duodenal adenocarcinomas, with an annual percentage change of 7.5 % (95 % CI 4.9–10.2 %,
p
< 0.001). Further, 29 % of all SBC patients had metastatic cancer at the time of diagnosis and 32 % had one or more synchronous/metachronous cancers. All morphological subtypes were associated with poor 5-year prognoses, in particular duodenal adenocarcinomas, with a 5-year survival rate of only 16 % (95 % CI 12–22 %).
Conclusions
The incidence of SBC has increased in recent decades, mainly because of a large increase in the incidence of duodenal adenocarcinomas, which are also associated with the poorest prognosis.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26847562</pmid><doi>10.1007/s00535-016-1171-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3998-1160</orcidid></addata></record> |
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source | Springer Nature |
subjects | Abdominal Surgery Adenocarcinoma - diagnosis Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adolescent Adult Aged Aged, 80 and over Cancer Cohort Studies Colorectal cancer Colorectal Surgery Denmark - epidemiology Female Gastroenterology Genetic aspects Hepatology Humans Incidence Intestinal Neoplasms - diagnosis Intestinal Neoplasms - epidemiology Intestinal Neoplasms - pathology Intestine, Small - pathology Male Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Metastasis Neoplasm Staging Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - epidemiology Neoplasms, Multiple Primary - pathology Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - pathology Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - epidemiology Neuroendocrine Tumors - pathology Oncology, Experimental Original Article—Alimentary Tract Phenotype Prognosis Registries Sarcoma - diagnosis Sarcoma - epidemiology Sarcoma - pathology Surgical Oncology Survival Analysis Young Adult |
title | Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study |
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