Incidence of, phenotypes of and survival from small bowel cancer in Denmark, 1994–2010: a population-based study

Background Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer o...

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Bibliographic Details
Published in:Journal of gastroenterology 2016-09, Vol.51 (9), p.891-899
Main Authors: Bojesen, Rasmus Dahlin, Andersson, Mikael, Riis, Lene Buhl, Nielsen, Ole Haagen, Jess, Tine
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adenocarcinoma - diagnosis
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adolescent
Adult
Aged
Aged, 80 and over
Cancer
Cohort Studies
Colorectal cancer
Colorectal Surgery
Denmark - epidemiology
Female
Gastroenterology
Genetic aspects
Hepatology
Humans
Incidence
Intestinal Neoplasms - diagnosis
Intestinal Neoplasms - epidemiology
Intestinal Neoplasms - pathology
Intestine, Small - pathology
Male
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Neoplasms, Multiple Primary - diagnosis
Neoplasms, Multiple Primary - epidemiology
Neoplasms, Multiple Primary - pathology
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - pathology
Neuroendocrine Tumors - diagnosis
Neuroendocrine Tumors - epidemiology
Neuroendocrine Tumors - pathology
Oncology, Experimental
Original Article—Alimentary Tract
Phenotype
Prognosis
Registries
Sarcoma - diagnosis
Sarcoma - epidemiology
Sarcoma - pathology
Surgical Oncology
Survival Analysis
Young Adult
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Summary:Background Small bowel cancer (SBC) is a rare and highly heterogeneous disease in respect to both anatomical distribution and histological morphology. We aimed to conduct a Danish nationwide population-based cohort study of the incidence of, phenotypes of, stage of, synchronous/metachronous cancer occurrence of and survival from SBC during 1994–2010. Methods The study population included all individuals aged 16 years or older living in Denmark during 1994–2010 ( n  = 7,070,142). Patients with SBC were identified through the Danish Cancer Registry. Incidence rates were calculated overall and according to the anatomical origin and morphological subtype. Patients were followed up from the date of cancer diagnosis to the date of emigration, death or the end of the study (31 December 2010). Results SBC was diagnosed in 1088 patients during 1994–2010. The total annual incidence of SBC was 1.10 per 100,000 [95 % confidence interval (CI) 1.04 to 1.17 per 100,000], with an annual percentage change of 1.9 % (95 % CI 0.6–3.1 %, p  = 0.003) during the observation period. This increase was mainly explained by an increase in the occurrence of duodenal adenocarcinomas, with an annual percentage change of 7.5 % (95 % CI 4.9–10.2 %, p  
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-016-1171-7