Prevalence of anxiety in Parkinson's disease: A systematic review and meta-analysis

ABSTRACT Objective Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD. Methods Using PubMed,...

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Bibliographic Details
Published in:Movement disorders 2016-08, Vol.31 (8), p.1125-1133
Main Authors: Broen, Martijn P. G., Narayen, Nadia E., Kuijf, Mark L., Dissanayaka, Nadeeka N. W., Leentjens, Albert F. G.
Format: Article
Language:English
Subjects:
Anxiety
Anxiety disorders
Anxiety Disorders - epidemiology
Comorbidity
Fear & phobias
Humans
Meta-analysis
Movement disorders
Panic attacks
Parkinson Disease - epidemiology
Parkinson's disease
review
Systematic review
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Summary:ABSTRACT Objective Prevalence rates of anxiety disorders in Parkinson's disease (PD) vary widely, ranging from 6% up to 55%. The aim of this systematic review was to calculate the average point prevalence of anxiety disorders and clinically relevant anxiety symptoms in PD. Methods Using PubMed, we carried out a systematic literature search for studies reporting Diagnostic and Statistical Manual–defined anxiety disorders or clinically relevant anxiety symptoms assessed by an anxiety rating scale. Results A total of 49 articles were included and assessed for quality, and 45 articles fulfilled the quality criteria. The average point prevalence of anxiety disorders in PD was 31%, with nonepisodic anxiety being more prevalent than episodic anxiety. Generalized anxiety disorder was the most frequent in 14%, followed by social phobia (13.8%), anxiety not otherwise specified (13.3%), and specific phobia (13.0%). Panic disorder with or without phobia was present in 6.8% of PD patients. Of the patients, 31% fulfilled the criteria for current multiple anxiety disorders. Based on anxiety rating scale cutoff scores, clinically significant anxiety symptoms were present in a weighted average of 25.7%. Conclusion This systematic review confirms that anxiety, although often unrecognized, is very common and highlights the need for efficient identification of anxiety in PD. © 2016 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26643