Recurrent pre‐eclampsia in women with metabolic syndrome and low plasma volume: a retrospective cohort study

Objective To determine the prevalence of recurrent pre‐eclampsia in women with a history of pre‐eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity. Design Retrospective cohort study. Setting Three tertiary referral hospitals in the N...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2015-12, Vol.122 (13), p.1773-1780
Main Authors: Stekkinger, E, Scholten, RR, Heidema, WM, Spaanderman, MEA
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Female
Humans
Metabolic syndrome
Metabolic Syndrome - epidemiology
Netherlands - epidemiology
Obstetrics
Plasma
plasma volume
Plasma Volume - physiology
Postpartum Period
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
Prevalence
pre‐eclampsia
Recurrence
Retrospective Studies
Risk Factors
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Summary:Objective To determine the prevalence of recurrent pre‐eclampsia in women with a history of pre‐eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity. Design Retrospective cohort study. Setting Three tertiary referral hospitals in the Netherlands. Population Women with a history of pre‐eclampsia. Methods In 196 women with a history of pre‐eclampsia we determined the presence or absence of metabolic syndrome using the World Health Organization criteria and measured plasma volume with the 125I‐human serum albumin indicator dilution technique. We compared the prevalence of recurrent pre‐eclampsia in four groups, classified according to presence or absence of metabolic syndrome and low or normal plasma volume, calculating odds ratios (OR), adjusted for confounders. Main outcome measure Recurrence of pre‐eclampsia in the subsequent pregnancy. Results The prevalence of recurrent pre‐eclampsia was 12% (12/99) in women without metabolic syndrome with normal plasma volume, versus 47% (8/17) in women with both metabolic syndrome and low plasma volume: OR 6.44 (95% CI 2.09–19.90), adjusted OR 7.90 (95% CI 2.30–27.16). Recurrent pre‐eclampsia was present in 44% (10/23) and 25% (14/57) of women with isolated metabolic syndrome and low plasma volume, respectively. Conclusions In the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre‐eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. Tweetable Metabolic syndrome and low plasma volume raise the risk of recurrent pre‐eclampsia to nearly 50%. Tweetable Metabolic syndrome and low plasma volume raise the risk of recurrent pre‐eclampsia to nearly 50%.
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.13737