Effects of metabolic syndrome on masseter muscle of male Wistar rats

The aim of this study was to investigate the association between metabolic syndrome (MetS) and the metabolic indicators of masticatory muscles in an animal model. A total of 16 male Wistar rats were used. To induce MetS, 10 rats were fed with standard rat chow and 32% sucrose solution ad libitum for...

Full description

Saved in:
Bibliographic Details
Published in:European journal of oral sciences 2015-12, Vol.123 (6), p.432-438
Main Authors: Tükel, H. Can, Alptekin, Özlem, Turan, Belma, Delilbaşı, Ertan
Format: Article
Language:English
Subjects:
Animals
Antioxidants
ATPases
Catalase
Dentistry
Glutathione Peroxidase
Male
Masseter Muscle
Metabolic Syndrome
Rats
Rats, Wistar
superoxide dismutase
trace elements
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate the association between metabolic syndrome (MetS) and the metabolic indicators of masticatory muscles in an animal model. A total of 16 male Wistar rats were used. To induce MetS, 10 rats were fed with standard rat chow and 32% sucrose solution ad libitum for 16 wk. Six rats fed with standard rat chow and water ad libitum formed the control group. All rats were killed at week 16, and the right superficial masseter muscles were harvested. Metabolic indicators of masticatory muscle metabolism, including antioxidant enzyme activities, ion transport ATPase activities, and the levels of macro and trace elements, were determined in the muscles. Superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities were significantly decreased by 32%, 26%, 33%, and 16%, respectively, in the MetS group. Na+/K+‐ATPase activity was significantly decreased in the MetS group by 54% compared with the control group. The levels of chromium and selenium were significantly decreased, and the level of copper was increased, in the MetS group compared with the control group. These results show that significant alterations occurred in antioxidant defense mechanisms, ion transport mechanisms, and trace element levels of masseter muscles in MetS.
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12226