Tumour thrombus consistency has no impact on survival in patients with renal cell carcinoma

The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus consistency (TTC) on overall survival remain contr...

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Bibliographic Details
Published in:Polish journal of pathology 2016-01, Vol.67 (2), p.145-150
Main Authors: Gołąbek, T, Przydacz, M, Okoń, K, Kopczyński, J, Bukowczan, J, Sobczyński, R, Curyło, Ł, Gołąbek, K, Chłosta, P
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood clots
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Demographics
Female
Humans
Kaplan-Meier Estimate
Kidney cancer
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Lymphatic system
Male
Medical prognosis
Metastasis
Middle Aged
Prognosis
Renal cell carcinoma
Retrospective Studies
Surgery
Venous Thrombosis - pathology
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Summary:The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus consistency (TTC) on overall survival remain controversial. The aim of this study was to investigate the prognostic role of TTC in patients' survival. We determined the tumour thrombus consistency (solid vs. friable) in a cohort of 84 patients with RCC and VTT who underwent nephrectomy with thrombectomy, and performed a retrospective evaluation of the patients' data from the prospectively maintained database. A total of 45% of patients had solid thrombus (sTT) and 55% had friable thrombus (fTT). The venous tumour thrombus consistency was not predictive of overall survival. Further studies, preferably prospective and with a larger number of patients, are needed to validate the obtained results, as well as to evaluate the usefulness of tumour thrombus consistency in clinical practice for stratifying the risk of recurrence and planning further follow-up.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2016.61143