Plasma total and unacylated ghrelin predict 5-year changes in insulin resistance

Summary Background & aims Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UG) forms, and higher plasma total ghrelin (TG) and UG may be cross-sectionally associated with lower insulin resistance in metabolic syndrome patients. The potential value of ghrelin forms in pre...

Full description

Saved in:
Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2016-10, Vol.35 (5), p.1168-1173
Main Authors: Barazzoni, R, Gortan Cappellari, G, Semolic, A, Ius, M, Mamolo, L, Dore, F, Giacca, M, Zanetti, M, Vinci, P, Guarnieri, G
Format: Article
Language:English
Subjects:
Acylation
Adult
Aged
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
C-Reactive Protein - metabolism
Cholesterol - blood
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Gastroenterology and Hepatology
Ghrelin
Ghrelin - blood
Humans
Insulin - blood
Insulin Resistance
Italy - epidemiology
Linear Models
Male
Metabolic Syndrome - blood
Middle Aged
Prospective Studies
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background & aims Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UG) forms, and higher plasma total ghrelin (TG) and UG may be cross-sectionally associated with lower insulin resistance in metabolic syndrome patients. The potential value of ghrelin forms in predicting insulin resistance and its time-related changes in community-based population cohorts remains unknown. Methods We measured TG, AG and calculated UG (TG-AG) in 716 individuals from the North-East-Italy MoMa study (age: 55 ± 9 years, BMI: 29 ± 5 kg/m2 , M/F:349/367) to test the hypothesis that circulating TG and UG, but not AG are negatively associated with insulin resistance (HOMA). We further hypothesized that baseline TG and UG negatively predict 5-year HOMA changes in a 350-individual subgroup. Results Baseline TG and UG were associated negatively with HOMA after adjusting for gender and body mass index (BMI). Baseline gender- and BMI-adjusted TG and UG were also negatively associated with HOMA at 5-year follow-up (n = 350), and changes in TG and UG were negatively associated with changes in HOMA (P 
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2015.10.002