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degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma super(E) activity
DegS (HhoB), a putative serine protease related to DegP/HtrA, regulates the basal and induced activity of the essential Escherichia coli sigma factor sigma super(E), which is involved in the cellular response to extracytoplasmic stress. DegS promotes the destabilization of the sigma super(E)-specifi...
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Published in: | Molecular microbiology 2001-06, Vol.40 (6), p.1323-1333 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | DegS (HhoB), a putative serine protease related to DegP/HtrA, regulates the basal and induced activity of the essential Escherichia coli sigma factor sigma super(E), which is involved in the cellular response to extracytoplasmic stress. DegS promotes the destabilization of the sigma super(E)-specific anti-sigma factor RseA, thereby releasing sigma super(E) to direct gene expression. We demonstrate that degS is an essential E. coli gene and show that the essential function of DegS is to provide the cell with sigma super(E) activity. We also show that the putative active site of DegS is periplasmic and that DegS requires its N-terminal transmembrane domain for its sigma super(E)-related function. |
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ISSN: | 0950-382X |
DOI: | 10.1046/j.1365-2958.2001.02475.x |