Spotlighted Brains: Optogenetic Activation and Silencing of Neurons

Optogenetics is revolutionizing cell biology and neuroscience research by allowing precise biochemical control of neuronal activity through light-activated channels. Light-induced ion transporters have been used extensively for cellular activation, and now light-gated inhibitory channels have been d...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2015-11, Vol.40 (11), p.624-627
Main Authors: Kianianmomeni, Arash, Hallmann, Armin
Format: Article
Language:English
Subjects:
Animals
Brain - physiology
Channelrhodopsins
Light
Neurons - physiology
Optical neuronal silencers
Optogenetics
Rhodopsin-like photoreceptors
Synthetic biology
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Summary:Optogenetics is revolutionizing cell biology and neuroscience research by allowing precise biochemical control of neuronal activity through light-activated channels. Light-induced ion transporters have been used extensively for cellular activation, and now light-gated inhibitory channels have been discovered. These represent a key new tool to elucidate the molecular mechanisms underlying neurological and neuropsychiatric disorders.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2015.09.004