The ubiquitin–proteasome system and its potential application in hepatocellular carcinoma therapy

Highlights • The ubiquitin–proteasome system plays an important role in cells throughout the body. • The UPS attracts considerable attention as potential target for HCC therapy. • Many UPS inhibitors (BZB, CZB, etc.) are investigated as the novel chemical drugs. • Future explorations will magnify sp...

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Bibliographic Details
Published in:Cancer letters 2016-09, Vol.379 (2), p.245-252
Main Authors: Chen, Yan-Jie, Wu, Hao, Shen, Xi-Zhong
Format: Article
Language:English
Subjects:
Animals
Antigens
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - metabolism
Bortezomib - therapeutic use
Cancer therapies
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - enzymology
Carcinoma, Hepatocellular - pathology
Cell cycle
Clinical trials
Conflicts of interest
Drug Design
Enzymes
Hematology, Oncology and Palliative Medicine
Hepatitis
Hepatocellular carcinoma
Humans
Hypoxia
Inhibitor
Kinases
Liver cancer
Liver Neoplasms - drug therapy
Liver Neoplasms - enzymology
Liver Neoplasms - pathology
Molecular Targeted Therapy
Oligopeptides - therapeutic use
Proteasome Endopeptidase Complex - metabolism
Proteasome Inhibitors - therapeutic use
Protein Processing, Post-Translational - drug effects
Proteins
Transcription factors
Treatment
Ubiquitination
Ubiquitin–proteasome system
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Summary:Highlights • The ubiquitin–proteasome system plays an important role in cells throughout the body. • The UPS attracts considerable attention as potential target for HCC therapy. • Many UPS inhibitors (BZB, CZB, etc.) are investigated as the novel chemical drugs. • Future explorations will magnify specificity of drugs.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.06.023