Initial radiographic tumor control is similar following single or multi-fractionated stereotactic radiosurgery for jugular paragangliomas

Abstract Objective To evaluate radiographic tumor control and treatment-related toxicity in glomus jugulare tumors treated with stereotactic radiosurgery (SRS). Study design Retrospective chart review. Setting Tertiary academic referral center. Patients Glomus jugulare tumors treated with SRS betwee...

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Bibliographic Details
Published in:American journal of otolaryngology 2016-05, Vol.37 (3), p.255-258
Main Authors: Schuster, Daniel, MD, Sweeney, Alex D., MD, Stavas, Mark J., MD, Tawfik, Kyrollos Y., BS, Attia, Albert, MD, Cmelak, Anthony J., MD, Wanna, George B., MD
Format: Article
Language:English
Subjects:
Adult
Aged
Dose Fractionation
Female
Glomus Jugulare Tumor - diagnostic imaging
Glomus Jugulare Tumor - pathology
Glomus Jugulare Tumor - therapy
Humans
Male
Middle Aged
Otolaryngology
Radiography
Radiosurgery
Retrospective Studies
Surgery
Treatment Outcome
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Summary:Abstract Objective To evaluate radiographic tumor control and treatment-related toxicity in glomus jugulare tumors treated with stereotactic radiosurgery (SRS). Study design Retrospective chart review. Setting Tertiary academic referral center. Patients Glomus jugulare tumors treated with SRS between 1998 and 2014 were identified. The data analysis only included patients with at least 18 months of post-treatment follow up (FU). Intervention Patients were treated with either single fraction or fractionated SRS. Main outcome measure Patient demographics and tumor characteristics were assessed. Radiographic control was determined by comparing pre and post treatment MRI, and was categorized as no change, regression, or progression. Results Eighteen patients were treated with SRS, and 14 met inclusion criteria. Median age at treatment was 55 years (range 35–79), and 71.4% of patients were female. 5 patients (35.7%) received single fraction SRS (dose range 15–18 Gy), and 9 (64.3%) fractionated therapy (dose 3–7 Gy × 3–15 fractions). Median tumor volume was 3.78 cm3 (range 1.15–30.6). Median FU was 28.8 months (range 18.6–56.1), with a mean of 31.7 months. At their last recorded MRI, 7 patients (50%) had tumor stability, 6 (42.9%) had improvement, and 1 (7.1%) had progression. Disease improvement and progression rates in the single fraction group were 40% and 0%, and in the multiple-fraction group, 44.4% and 11.1%, respectively. There was no statistically significant difference in disease improvement (p = 0.88) or progression (p = 0.48) rates between groups (unpaired t-test). Conclusions At a median follow up of 28 months, both single fraction and fractionated SRS appear to have comparable radiographic tumor control outcomes and toxicity profiles.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2016.01.002