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Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression
Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (...
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| Published in: | Psychiatry research. Neuroimaging 2016-07, Vol.253, p.26-35 |
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| container_title | Psychiatry research. Neuroimaging |
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| creator | Tsujii, Noa Mikawa, Wakako Tsujimoto, Emi Akashi, Hiroyuki Adachi, Toru Kirime, Eiji Shirakawa, Osamu |
| description | Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF. |
| doi_str_mv | 10.1016/j.pscychresns.2016.04.015 |
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We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2016.04.015</identifier><identifier>PMID: 27259838</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Cerebrovascular Circulation - physiology ; Depression - diagnostic imaging ; Depression - physiopathology ; Depression - psychology ; Depressive Disorder, Major - diagnostic imaging ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Female ; Hemodynamics - physiology ; Humans ; Major depressive disorder ; Male ; Melancholic depression ; Middle Aged ; Near-infrared spectroscopy ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - physiopathology ; Psychiatry ; Quality of Life - psychology ; Radiology ; SF-36 ; Spectroscopy, Near-Infrared - methods ; Young Adult</subject><ispartof>Psychiatry research. Neuroimaging, 2016-07, Vol.253, p.26-35</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-eb4b73d9be0d9f0c0eebc4f1545d735e2b4b97b633332c4ec0962a7aa2bdd6103</citedby><cites>FETCH-LOGICAL-c531t-eb4b73d9be0d9f0c0eebc4f1545d735e2b4b97b633332c4ec0962a7aa2bdd6103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27259838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsujii, Noa</creatorcontrib><creatorcontrib>Mikawa, Wakako</creatorcontrib><creatorcontrib>Tsujimoto, Emi</creatorcontrib><creatorcontrib>Akashi, Hiroyuki</creatorcontrib><creatorcontrib>Adachi, Toru</creatorcontrib><creatorcontrib>Kirime, Eiji</creatorcontrib><creatorcontrib>Shirakawa, Osamu</creatorcontrib><title>Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF.</description><subject>Adult</subject><subject>Aged</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Depression - diagnostic imaging</subject><subject>Depression - physiopathology</subject><subject>Depression - psychology</subject><subject>Depressive Disorder, Major - diagnostic imaging</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Female</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Melancholic depression</subject><subject>Middle Aged</subject><subject>Near-infrared spectroscopy</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatry</subject><subject>Quality of Life - psychology</subject><subject>Radiology</subject><subject>SF-36</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUstu1DAUtRAVHQZ-AZkdmwTbcV4bJDSCglQJqS1ry7FvNB4SO_VNirLnw-thSkGs6o2l6_OwzrmEvOUs54xX7w_5hGY1-wjoMRdplDOZM14-Ixve1CKrS1Y9JxvWijKTrajPyUvEA2OiaKriBTkXtSjbpmg25NcVDHp2wePeTbSD-SeAp1OEPgY_64HuYQx29Xp0hia_KSEBqfaW3i56cPNKQ08H1wO1ru8h4qPImJS92YfB6d94H3z2d2aohWSDmLxfkbNeDwivH-4t-f75083uS3b57eLr7uNlZsqCzxl0sqsL23bAbNszwwA6I3teytLWRQkivbd1VxXpCCPBsLYSutZadNZWnBVb8u6kO8VwuwDOanRoYEh_grCg4g3nTVPx5ilQxqVoZUpxS9oT1MSAmJJTU3SjjqviTB37Ugf1T1_q2JdiUqW-EvfNg83SjWAfmX8KSoDdCQAplzsHUaFx4A1YF8HMygb3JJsP_6mYwXln9PADVsBDWKJPwSuuUCimro-Lc9ybRGWcM1ncA88Txfc</recordid><startdate>20160730</startdate><enddate>20160730</enddate><creator>Tsujii, Noa</creator><creator>Mikawa, Wakako</creator><creator>Tsujimoto, Emi</creator><creator>Akashi, Hiroyuki</creator><creator>Adachi, Toru</creator><creator>Kirime, Eiji</creator><creator>Shirakawa, Osamu</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160730</creationdate><title>Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression</title><author>Tsujii, Noa ; Mikawa, Wakako ; Tsujimoto, Emi ; Akashi, Hiroyuki ; Adachi, Toru ; Kirime, Eiji ; Shirakawa, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-eb4b73d9be0d9f0c0eebc4f1545d735e2b4b97b633332c4ec0962a7aa2bdd6103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Depression - diagnostic imaging</topic><topic>Depression - physiopathology</topic><topic>Depression - psychology</topic><topic>Depressive Disorder, Major - diagnostic imaging</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Female</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Melancholic depression</topic><topic>Middle Aged</topic><topic>Near-infrared spectroscopy</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatry</topic><topic>Quality of Life - psychology</topic><topic>Radiology</topic><topic>SF-36</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsujii, Noa</creatorcontrib><creatorcontrib>Mikawa, Wakako</creatorcontrib><creatorcontrib>Tsujimoto, Emi</creatorcontrib><creatorcontrib>Akashi, Hiroyuki</creatorcontrib><creatorcontrib>Adachi, Toru</creatorcontrib><creatorcontrib>Kirime, Eiji</creatorcontrib><creatorcontrib>Shirakawa, Osamu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsujii, Noa</au><au>Mikawa, Wakako</au><au>Tsujimoto, Emi</au><au>Akashi, Hiroyuki</au><au>Adachi, Toru</au><au>Kirime, Eiji</au><au>Shirakawa, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res Neuroimaging</addtitle><date>2016-07-30</date><risdate>2016</risdate><volume>253</volume><spage>26</spage><epage>35</epage><pages>26-35</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>27259838</pmid><doi>10.1016/j.pscychresns.2016.04.015</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Cerebrovascular Circulation - physiology Depression - diagnostic imaging Depression - physiopathology Depression - psychology Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Female Hemodynamics - physiology Humans Major depressive disorder Male Melancholic depression Middle Aged Near-infrared spectroscopy Prefrontal Cortex - blood supply Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiopathology Psychiatry Quality of Life - psychology Radiology SF-36 Spectroscopy, Near-Infrared - methods Young Adult |
| title | Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression |
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