Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression

Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2016-07, Vol.253, p.26-35
Main Authors: Tsujii, Noa, Mikawa, Wakako, Tsujimoto, Emi, Akashi, Hiroyuki, Adachi, Toru, Kirime, Eiji, Shirakawa, Osamu
Format: Article
Language:English
Subjects:
Adult
Aged
Cerebrovascular Circulation - physiology
Depression - diagnostic imaging
Depression - physiopathology
Depression - psychology
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Female
Hemodynamics - physiology
Humans
Major depressive disorder
Male
Melancholic depression
Middle Aged
Near-infrared spectroscopy
Prefrontal Cortex - blood supply
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiopathology
Psychiatry
Quality of Life - psychology
Radiology
SF-36
Spectroscopy, Near-Infrared - methods
Young Adult
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Summary:Abstract This study aimed to determine whether quality of life (QOL) reflects specific functional abnormalities of frontotemporal hemodynamic responses in melancholia. We recruited 30 patients with major depressive disorder (MDD) with melancholic features (MDD-MF), 52 with non-melancholic features (MDD-NMF), and 68 healthy control subjects who were matched for age, sex ratio, and years of education. QOL was assessed using the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), and regional hemodynamic responses during a verbal fluency task were monitored with near-infrared spectroscopy (NIRS). Patients with MDD-MF scored significantly lower than those with MDD-NMF on the role emotional domain of SF-36. Both MDD patient groups exhibited lower hemodynamic responses in the frontotemporal regions than the control group. Hemodynamic responses in the frontotemporal regions were significantly smaller in patients with MDD-MF than in those with MDD-NMF. The role emotional domain of patients with MDD-MF was significantly and positively correlated with hemodynamic responses in the prefrontal region, whereas that of patients with MDD-NMF revealed no significant correlation. In conclusion, our results indicate that patients with MDD-MF exhibit qualitatively distinct prefrontal dysfunction patterns associated with emotional role functioning compared with patients with MDD-NMF.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2016.04.015