Audiological Manifestations in Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke like Episodes (MELAS) Syndrome

Highlights • Eight patients with MELAS syndrome and m.3243 A > G mutation underwent audiological evaluation. • Sensory neural hearing loss of subclinical to severe degree was present in five patients. • Hearing loss of cochlear origin was seen in four and retro cochlear origin in one. • Early ref...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2016-09, Vol.148, p.17-21
Main Authors: Vandana, V.P, Bindu, Parayil Sankaran, Sonam, Kothari, Govindaraj, Periyasamy, Taly, Arun B, Gayathri, Narayanappa, Chiplunkar, Shwetha, Govindraju, Chikkanna, Arvinda, H.R, Nagappa, Madhu, Sinha, Sanjib, Thangaraj, K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Auditory neuropathy
Biopsy
Calcification
Child
Child, Preschool
Emissions
Female
Hearing loss
Hearing Loss - diagnosis
Hearing Loss - etiology
Hearing Loss, Sensorineural - diagnosis
Hearing Loss, Sensorineural - etiology
Hearing protection
Humans
m.3243A > G
Male
Medical imaging
MELAS
MELAS Syndrome - complications
Middle Aged
Mutation
Neurology
Neurosurgery
NMR
Nuclear magnetic resonance
Patients
Sensory neural deafness
Stroke
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Summary:Highlights • Eight patients with MELAS syndrome and m.3243 A > G mutation underwent audiological evaluation. • Sensory neural hearing loss of subclinical to severe degree was present in five patients. • Hearing loss of cochlear origin was seen in four and retro cochlear origin in one. • Early referrals for audiological evaluation may detect subclinical hearing loss in MELAS.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2016.04.024