Laboratory confirmation of rubella infection in suspected measles cases

As a part of measles outbreak based surveillance undertaken by the World Health Organization India, suspected measles cases were referred for the laboratory diagnosis at National Institute of Virology (NIV) Pune and NIV Unit Bengaluru. Altogether, 4,592 serum samples were referred during 2010–2015 f...

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Bibliographic Details
Published in:Journal of medical virology 2016-10, Vol.88 (10), p.1685-1689
Main Authors: Vaidya, Sunil R., Raut, Chandrashekhar G., Jadhav, Santoshkumar M.
Format: Article
Language:English
Subjects:
Adolescent
Antibodies, Viral - blood
Child
Child, Preschool
Disease Outbreaks
Epidemiological Monitoring
Epidemiology
Female
Humans
Immunoglobulin M - blood
India
India - epidemiology
Infant
Karnataka
Kerala
laboratory diagnosis
Maharashtra
Male
Measles
Measles - diagnosis
Measles - epidemiology
Measles - immunology
Measles Vaccine
rubella
Rubella - diagnosis
Rubella - epidemiology
Rubella - immunology
Rubella - virology
Rubella virus - immunology
Serologic Tests
Vaccination
Virology
Young Adult
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Summary:As a part of measles outbreak based surveillance undertaken by the World Health Organization India, suspected measles cases were referred for the laboratory diagnosis at National Institute of Virology (NIV) Pune and NIV Unit Bengaluru. Altogether, 4,592 serum samples were referred during 2010–2015 from the States of Karnataka (n = 1,173), Kerala (n = 559), and Maharashtra (n = 2,860). Initially, serum samples were tested in measles IgM antibody EIA and samples with measles negative and equivocal results (n = 1,954) were subjected to rubella IgM antibody detection. Overall, 62.9% (2,889/4,592) samples were laboratory confirmed measles, 27.7% (542/1,954) were laboratory confirmed rubella and remaining 25.2% (1,161/4,592) were negative for measles and rubella. The measles vaccination status was available for 1,206 cases. Among the vaccinated individuals, 50.7% (612/1,206) were laboratory confirmed measles. The contribution of laboratory confirmed measles was 493 (40.8%) from Maharashtra, 90 (7.5%) from Karnataka, and 29 (2.4%) from Kerala. Since, 1/3rd of suspected measles cases were laboratory confirmed rubella, an urgent attention needed to build rubella surveillance in India. Additional efforts are required to rule out other exanthematous disease including Dengue and Chikungunya in measles and rubella negatives. J. Med. Virol. 88:1685–1689, 2016. © 2016 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24535