Loading…
Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation
Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrat...
Saved in:
| Published in: | Materials Science & Engineering C 2016-11, Vol.68, p.229-240 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3 |
| container_end_page | 240 |
| container_issue | |
| container_start_page | 229 |
| container_title | Materials Science & Engineering C |
| container_volume | 68 |
| creator | Xu, Jia-yun Chen, Xian-shuai Zhang, Chun-yu Liu, Yun Wang, Jing Deng, Fei-long |
| description | Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrate was optimized by sandblasting, and nano-porous features of orderly arranged nanotubes and disorderly arranged nanonet were produced by anodization (SAN) and alkali-heat treatment (SAH), respectively. The results were compared with the control group of an untreated surface (native-SLM) and a microtopography only surface treated by acid etching (SLA). The effects of the different topographies on cell functions and bone formation performance were evaluated in vitro and in vivo. It was found that micro-/nano-textured topographies of SAN and SAH showed enhanced cell behaviour relative to the microtopography of SLA with significantly higher proliferation on the 1st, 3rd, 5th and 7th day (P |
| doi_str_mv | 10.1016/j.msec.2016.05.096 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1811841970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S092849311630529X</els_id><sourcerecordid>1811841970</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhi0EomnhBTggH7ns1vZmvV7EBVVQKlXiQO-WY48TR2t7sb0peSjeEacpHDl5PPrnH83_IfSOkpYSyq_3rc-gW1brlvQtGfkLtKJi6BpCR_oSrcjIRLMeO3qBLnPeE8JFN7DX6IINPVsTOqzQ7zs_p3gAgzcuKl3cwZUjjhZnmOD0BTypDAl7mIoLW1xcUcEt_iP-sSSrNGAfjbNOq-JiwI-u7LB3OsXmOqgQmwK_ypKq_85BUknvqnLCJc5xm9S8O2IV6u4YACfYQqiaJ58Zko3Jq1AXwEFNy1P7DXpl1ZTh7fN7hR6-fnm4-dbcf7-9u_l83-hu7ErDKFeWDwzMxiq-5oQTYnjPR0Zpx_TAxKA3PTBRu8SAFcqCMXS0qu-YUN0V-nC2rdH8XCAX6V3WME0qQFyypIJSsabjQKqUnaX14pwTWDkn51U6SkrkiZLcyxMleaIkSS8rpTr0_tl_2Xgw_0b-YqmCT2cB1CMPNTiZtYOahXGpUpEmuv_5_wHLJqlM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1811841970</pqid></control><display><type>article</type><title>Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation</title><source>ScienceDirect Freedom Collection</source><creator>Xu, Jia-yun ; Chen, Xian-shuai ; Zhang, Chun-yu ; Liu, Yun ; Wang, Jing ; Deng, Fei-long</creator><creatorcontrib>Xu, Jia-yun ; Chen, Xian-shuai ; Zhang, Chun-yu ; Liu, Yun ; Wang, Jing ; Deng, Fei-long</creatorcontrib><description>Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrate was optimized by sandblasting, and nano-porous features of orderly arranged nanotubes and disorderly arranged nanonet were produced by anodization (SAN) and alkali-heat treatment (SAH), respectively. The results were compared with the control group of an untreated surface (native-SLM) and a microtopography only surface treated by acid etching (SLA). The effects of the different topographies on cell functions and bone formation performance were evaluated in vitro and in vivo. It was found that micro-/nano-textured topographies of SAN and SAH showed enhanced cell behaviour relative to the microtopography of SLA with significantly higher proliferation on the 1st, 3rd, 5th and 7th day (P<0.05) and higher total protein contents on the 14th day (P<0.05). In vivo, SAN and SAH formed more successively regenerated bone, which resulted in higher bone-implant contact (BIC%) and bone-bonding force than native-SLM and SLA. In addition, the three-dimensional nanonet of SAH was expected to be more similar to native extracellular matrix (ECM) and thus led to better bone formation. The alkaline phosphatase activity of SAH was significantly higher than the other three groups at an earlier stage of the 7th day (P<0.05) and the BIC% was nearly double that of native-SLM and SLA in the 8th week. In conclusion, the addition of nano-porous features on the microrough SLM titanium surface is effective in improving the bioactivity and bone regeneration performance, in which the ECM-like nanonet with a disorderly arranged biomimetic feature is suggested to be more efficient than nanotubes.
•SLM titanium is modified by adding nano-porous features to the microrough substrate.•Micro-/nano-topography surpasses microtopography in improving bone regeneration.•Micro-/nano-topography induces successive growth of bone on SLM titanium surface.•Alkali-heat treatment creates nanonet topography and hydrophilic surface as well.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2016.05.096</identifier><identifier>PMID: 27524017</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Bone Regeneration - drug effects ; Cell Line ; Lasers ; Materials Testing ; Mice ; Micro-/nano-topography ; Nano-porous ; Nanopores ; Osseointegration ; Osteoblasts - metabolism ; Selective laser melting ; Surface modification ; Titanium ; Titanium - chemistry ; Titanium - pharmacology ; Wettability</subject><ispartof>Materials Science & Engineering C, 2016-11, Vol.68, p.229-240</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3</citedby><cites>FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27524017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jia-yun</creatorcontrib><creatorcontrib>Chen, Xian-shuai</creatorcontrib><creatorcontrib>Zhang, Chun-yu</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Deng, Fei-long</creatorcontrib><title>Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrate was optimized by sandblasting, and nano-porous features of orderly arranged nanotubes and disorderly arranged nanonet were produced by anodization (SAN) and alkali-heat treatment (SAH), respectively. The results were compared with the control group of an untreated surface (native-SLM) and a microtopography only surface treated by acid etching (SLA). The effects of the different topographies on cell functions and bone formation performance were evaluated in vitro and in vivo. It was found that micro-/nano-textured topographies of SAN and SAH showed enhanced cell behaviour relative to the microtopography of SLA with significantly higher proliferation on the 1st, 3rd, 5th and 7th day (P<0.05) and higher total protein contents on the 14th day (P<0.05). In vivo, SAN and SAH formed more successively regenerated bone, which resulted in higher bone-implant contact (BIC%) and bone-bonding force than native-SLM and SLA. In addition, the three-dimensional nanonet of SAH was expected to be more similar to native extracellular matrix (ECM) and thus led to better bone formation. The alkaline phosphatase activity of SAH was significantly higher than the other three groups at an earlier stage of the 7th day (P<0.05) and the BIC% was nearly double that of native-SLM and SLA in the 8th week. In conclusion, the addition of nano-porous features on the microrough SLM titanium surface is effective in improving the bioactivity and bone regeneration performance, in which the ECM-like nanonet with a disorderly arranged biomimetic feature is suggested to be more efficient than nanotubes.
•SLM titanium is modified by adding nano-porous features to the microrough substrate.•Micro-/nano-topography surpasses microtopography in improving bone regeneration.•Micro-/nano-topography induces successive growth of bone on SLM titanium surface.•Alkali-heat treatment creates nanonet topography and hydrophilic surface as well.</description><subject>Animals</subject><subject>Bone Regeneration - drug effects</subject><subject>Cell Line</subject><subject>Lasers</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Micro-/nano-topography</subject><subject>Nano-porous</subject><subject>Nanopores</subject><subject>Osseointegration</subject><subject>Osteoblasts - metabolism</subject><subject>Selective laser melting</subject><subject>Surface modification</subject><subject>Titanium</subject><subject>Titanium - chemistry</subject><subject>Titanium - pharmacology</subject><subject>Wettability</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuEzEQhi0EomnhBTggH7ns1vZmvV7EBVVQKlXiQO-WY48TR2t7sb0peSjeEacpHDl5PPrnH83_IfSOkpYSyq_3rc-gW1brlvQtGfkLtKJi6BpCR_oSrcjIRLMeO3qBLnPeE8JFN7DX6IINPVsTOqzQ7zs_p3gAgzcuKl3cwZUjjhZnmOD0BTypDAl7mIoLW1xcUcEt_iP-sSSrNGAfjbNOq-JiwI-u7LB3OsXmOqgQmwK_ypKq_85BUknvqnLCJc5xm9S8O2IV6u4YACfYQqiaJ58Zko3Jq1AXwEFNy1P7DXpl1ZTh7fN7hR6-fnm4-dbcf7-9u_l83-hu7ErDKFeWDwzMxiq-5oQTYnjPR0Zpx_TAxKA3PTBRu8SAFcqCMXS0qu-YUN0V-nC2rdH8XCAX6V3WME0qQFyypIJSsabjQKqUnaX14pwTWDkn51U6SkrkiZLcyxMleaIkSS8rpTr0_tl_2Xgw_0b-YqmCT2cB1CMPNTiZtYOahXGpUpEmuv_5_wHLJqlM</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Xu, Jia-yun</creator><creator>Chen, Xian-shuai</creator><creator>Zhang, Chun-yu</creator><creator>Liu, Yun</creator><creator>Wang, Jing</creator><creator>Deng, Fei-long</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation</title><author>Xu, Jia-yun ; Chen, Xian-shuai ; Zhang, Chun-yu ; Liu, Yun ; Wang, Jing ; Deng, Fei-long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Bone Regeneration - drug effects</topic><topic>Cell Line</topic><topic>Lasers</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Micro-/nano-topography</topic><topic>Nano-porous</topic><topic>Nanopores</topic><topic>Osseointegration</topic><topic>Osteoblasts - metabolism</topic><topic>Selective laser melting</topic><topic>Surface modification</topic><topic>Titanium</topic><topic>Titanium - chemistry</topic><topic>Titanium - pharmacology</topic><topic>Wettability</topic><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jia-yun</creatorcontrib><creatorcontrib>Chen, Xian-shuai</creatorcontrib><creatorcontrib>Zhang, Chun-yu</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Deng, Fei-long</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jia-yun</au><au>Chen, Xian-shuai</au><au>Zhang, Chun-yu</au><au>Liu, Yun</au><au>Wang, Jing</au><au>Deng, Fei-long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>68</volume><spage>229</spage><epage>240</epage><pages>229-240</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrate was optimized by sandblasting, and nano-porous features of orderly arranged nanotubes and disorderly arranged nanonet were produced by anodization (SAN) and alkali-heat treatment (SAH), respectively. The results were compared with the control group of an untreated surface (native-SLM) and a microtopography only surface treated by acid etching (SLA). The effects of the different topographies on cell functions and bone formation performance were evaluated in vitro and in vivo. It was found that micro-/nano-textured topographies of SAN and SAH showed enhanced cell behaviour relative to the microtopography of SLA with significantly higher proliferation on the 1st, 3rd, 5th and 7th day (P<0.05) and higher total protein contents on the 14th day (P<0.05). In vivo, SAN and SAH formed more successively regenerated bone, which resulted in higher bone-implant contact (BIC%) and bone-bonding force than native-SLM and SLA. In addition, the three-dimensional nanonet of SAH was expected to be more similar to native extracellular matrix (ECM) and thus led to better bone formation. The alkaline phosphatase activity of SAH was significantly higher than the other three groups at an earlier stage of the 7th day (P<0.05) and the BIC% was nearly double that of native-SLM and SLA in the 8th week. In conclusion, the addition of nano-porous features on the microrough SLM titanium surface is effective in improving the bioactivity and bone regeneration performance, in which the ECM-like nanonet with a disorderly arranged biomimetic feature is suggested to be more efficient than nanotubes.
•SLM titanium is modified by adding nano-porous features to the microrough substrate.•Micro-/nano-topography surpasses microtopography in improving bone regeneration.•Micro-/nano-topography induces successive growth of bone on SLM titanium surface.•Alkali-heat treatment creates nanonet topography and hydrophilic surface as well.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27524017</pmid><doi>10.1016/j.msec.2016.05.096</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0928-4931 |
| ispartof | Materials Science & Engineering C, 2016-11, Vol.68, p.229-240 |
| issn | 0928-4931 1873-0191 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1811841970 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Bone Regeneration - drug effects Cell Line Lasers Materials Testing Mice Micro-/nano-topography Nano-porous Nanopores Osseointegration Osteoblasts - metabolism Selective laser melting Surface modification Titanium Titanium - chemistry Titanium - pharmacology Wettability |
| title | Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T02%3A23%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improved%20bioactivity%20of%20selective%20laser%20melting%20titanium:%20Surface%20modification%20with%20micro-/nano-textured%20hierarchical%20topography%20and%20bone%20regeneration%20performance%20evaluation&rft.jtitle=Materials%20Science%20&%20Engineering%20C&rft.au=Xu,%20Jia-yun&rft.date=2016-11-01&rft.volume=68&rft.spage=229&rft.epage=240&rft.pages=229-240&rft.issn=0928-4931&rft.eissn=1873-0191&rft_id=info:doi/10.1016/j.msec.2016.05.096&rft_dat=%3Cproquest_cross%3E1811841970%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c393t-216af672edbfa6460600d656921132c7287cb5e280d60def8afedd19fa5328a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1811841970&rft_id=info:pmid/27524017&rfr_iscdi=true |