Improved bioactivity of selective laser melting titanium: Surface modification with micro-/nano-textured hierarchical topography and bone regeneration performance evaluation

Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrat...

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Bibliographic Details
Published in:Materials Science & Engineering C 2016-11, Vol.68, p.229-240
Main Authors: Xu, Jia-yun, Chen, Xian-shuai, Zhang, Chun-yu, Liu, Yun, Wang, Jing, Deng, Fei-long
Format: Article
Language:English
Subjects:
Animals
Bone Regeneration - drug effects
Cell Line
Lasers
Materials Testing
Mice
Micro-/nano-topography
Nano-porous
Nanopores
Osseointegration
Osteoblasts - metabolism
Selective laser melting
Surface modification
Titanium
Titanium - chemistry
Titanium - pharmacology
Wettability
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Summary:Selective laser melting (SLM) titanium requires surface modification to improve its bioactivity. The microrough surface of it can be utilized as the micro primary substrate to create a micro-/nano-textured topography for improved bone regeneration. In this study, the microrough SLM titanium substrate was optimized by sandblasting, and nano-porous features of orderly arranged nanotubes and disorderly arranged nanonet were produced by anodization (SAN) and alkali-heat treatment (SAH), respectively. The results were compared with the control group of an untreated surface (native-SLM) and a microtopography only surface treated by acid etching (SLA). The effects of the different topographies on cell functions and bone formation performance were evaluated in vitro and in vivo. It was found that micro-/nano-textured topographies of SAN and SAH showed enhanced cell behaviour relative to the microtopography of SLA with significantly higher proliferation on the 1st, 3rd, 5th and 7th day (P
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2016.05.096