The effect of oil-water partition coefficient on the distribution and cellular uptake of liposome-encapsulated gold nanoparticles

Oil-water partition coefficient effect of gold nanoparticles on their location in and cellular uptake of liposomes have been studied to reveal the property control of hybrid vehicle systems by simple surface chemistry of gold nanoparticles. [Display omitted] ⿢The oil-water partition coefficients (Kp...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-10, Vol.146, p.475-481
Main Authors: Bao, Quan-Ying, Liu, Ai-Yun, Ma, Yu, Chen, Huan, Hong, Jin, Shen, Wen-Bin, Zhang, Can, Ding, Ya
Format: Article
Language:English
Subjects:
Cellular uptake
Fluorescence
Gold - chemistry
Gold nanoparticles
Hep G2 Cells
Humans
Hybrid nanostructure
Hydrophobic and Hydrophilic Interactions
Liposomes
Liposomes - chemistry
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Oil-water partition coefficient
Oils - chemistry
Spectrophotometry, Atomic
Water - chemistry
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Summary:Oil-water partition coefficient effect of gold nanoparticles on their location in and cellular uptake of liposomes have been studied to reveal the property control of hybrid vehicle systems by simple surface chemistry of gold nanoparticles. [Display omitted] ⿢The oil-water partition coefficients (Kp) of gold conjugates.⿢Kp effects of gold conjugates on the location of gold conjugates in liposomes.⿢Kp effects of gold conjugates on the cellular uptake of hybrid liposomes.⿢Hydrophilicity differences of regions in the internal core and surface of liposomes.⿢Fine control of hybrid systems by simple surface chemistry of gold nanoparticles. The shape, size, and surface features of nanoparticles greatly influence the structure and properties of resulting hybrid nanosystems. In this work, gold nanoparticles (GNPs) were modified via S-Au covalent bonding by glycol monomethyl ether thioctate with poly(ethylene glycol) methyl ether of different molecular weights (i.e., 350, 550, and 750Da). These modified GNPs (i.e., GNP350, GNP550, and GNP750) showed different oil-water partition coefficients (Kp), as detected using inductively coupled plasma-atomic emission spectroscopy. The different Kp values of the gold conjugates (i.e., 13.98, 2.11, and 0.036 for GNP350, GNP550, and GNP750, respectively) resulted in different conjugate localization within liposomes, as observed by transmission electron microscopy. In addition, the cellular uptake of hybrid liposomes co-encapsulating gold conjugates and Nile red was evaluated using intracellular fluorescence intensity. The results indicated that precise GNP localization in the hydrophilic or hydrophobic liposome cavity could be achieved by regulating the GNP oil-water partition coefficient via surface modification; such localization could further affect the properties and functions of hybrid liposomes, including their cellular uptake profiles. This study furthers the understanding not only of the interaction between liposomes and inorganic nanoparticles but also of adjusting liposome-gold hybrid nanostructure properties via the surface chemistry of gold materials.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2016.06.046