Electrophysiological mechanisms of biased response to smoking-related cues in young smokers

•Brain responses were compared between young smokers and controls by employing ERP.•Abnormal cognitive processing of smoking-related cues was observed in young smokers.•The SPW of smoking-related cues was enhanced in young smokers compared with controls.•P300/SPW of smoking-related cues was larger t...

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Bibliographic Details
Published in:Neuroscience letters 2016-08, Vol.629, p.85-91
Main Authors: Cheng, Jiadong, Guan, Yanyan, Zhang, Yajuan, Bi, Yanzhi, Bu, Limei, Li, Yangding, Shi, Sha, Liu, Peng, Lu, Xiaoqi, Yu, Dahua, Yuan, Kai
Format: Article
Language:English
Subjects:
Adult
Cerebral Cortex - physiopathology
Cognition - physiology
Cognitive processing bias
Craving - physiology
Cues
Electroencephalography
Event-related potentials (ERP)
Event-Related Potentials, P300
Humans
Male
P300
Slow Positive Wave (SPW)
Smoking - physiopathology
Smoking - psychology
Young Adult
Young adult smokers
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Summary:•Brain responses were compared between young smokers and controls by employing ERP.•Abnormal cognitive processing of smoking-related cues was observed in young smokers.•The SPW of smoking-related cues was enhanced in young smokers compared with controls.•P300/SPW of smoking-related cues was larger than neutral cues in young smokers.•A positive correlation between CPD and P300/SPW was observed in young smokers. Cigarette smoking during young adult may result in serious health issues in later life. Hence, it is extremely necessary to study the smoking neurophysiological mechanisms in this critical transitional period. However, few studies revealed the electrophysiological mechanisms of cognitive processing biases in young adult smokers. In present study, nineteen young smokers with 12h abstinent and 19 matched nonsmokers were recruited. By employing event-related potentials (ERP) measurements during a smoking cue induced craving task, electrophysiological brain responses were compared between the young adult smokers and nonsmokers. The Slow Positive Wave (SPW) amplitude of smoking-related cues was enhanced in young adult smokers compared with nonsmokers. In addition, increased P300/SPW component of smoking-related cues relative to neutral cues were found in young adult smokers. Meanwhile, a positive correlation between Cigarette Per Day (CPD) and the amplitude of ERPs wave (P300/SPW) at anterior (Fz), central (Cz) were observed in young adult smokers. Our findings provided direct electrophysiological evidence for the cognitive processing bias of smoking cue and may shed new insights into the smoking behavior in young adult smokers.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2016.06.062