Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women

Purpose To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. Methods Premenopausal women ( n  = 136, mean age 41 (±5) y...

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Bibliographic Details
Published in:European journal of nutrition 2016-08, Vol.55 (5), p.1911-1921
Main Authors: Kruger, Marlena C., Chan, Yoke Mun, Kuhn-Sherlock, Barbara, Lau, Lee Ting, Lau, ChinChin, Chin, Y. S., Todd, Joanne M., Schollum, Linda M.
Format: Article
Language:English
Subjects:
Adult
Animals
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
Body Weight
Bone and Bones - metabolism
Bone Density
Bone Resorption - prevention & control
Calcium, Dietary - administration & dosage
Calcium, Dietary - blood
Chemistry
Chemistry and Materials Science
Collagen Type I - blood
Dietary Fats - administration & dosage
Dietary Fats - analysis
Female
Follow-Up Studies
Food, Fortified
Humans
Insulin - blood
Inulin - administration & dosage
Magnesium - blood
Middle Aged
Milk - chemistry
Nutrition
Original Contribution
Parathyroid Hormone - blood
Phosphorus - blood
Postmenopause - blood
Surveys and Questionnaires
Vitamin D - administration & dosage
Vitamin D - blood
Waist Circumference
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Summary:Purpose To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. Methods Premenopausal women ( n  = 136, mean age 41 (±5) years) and postmenopausal women [ n  = 121, mean age 59 (±4) years] were recruited, and each age group randomised into two groups to take two glasses per day of control = regular milk (500 mg calcium per day) or intervention (Int) = fortified milk (1000 mg calcium for pre-M women and 1200 mg calcium for PM women, 96 mg magnesium, 2.4 mg zinc, 15 µg vitamin D, 4 g FOS-inulin per day). At baseline, week 4 and week 12 serum minerals and bone biochemical markers were measured and bone density was measured at baseline. Results Mean 25-hydroxyvitamin D [25(OH) vitamin D 3 ] levels among groups were between 49 and 65 nmol/L at baseline, and over the 12 weeks of supplementation, the fortified milk improved vitamin D status in both Int groups. CTx-1 and PINP reduced significantly in both Pre-M and PM groups over the 12 weeks, with the changes in CTx-1 being significantly different ( P  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-015-1007-x