Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice

We studied ionotropic glutamate receptor subtypes and the effect of chronic treatment with NBQX [6‐nitro‐7‐sulphamoyl‐benzo(F)quinoxaline‐2,3‐dione], a selective (rs)‐α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptor antagonist, in the spinal cord of mnd mice. NBQX (8 mg/kg daily...

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Bibliographic Details
Published in:The European journal of neuroscience 1999-05, Vol.11 (5), p.1705-1710
Main Authors: Mennini, T., Cagnotto, A., Carvelli, L., Comoletti, D., Manzoni, C., Muzio, V., Rizzi, M., Vezzani, A.
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - analogs & derivatives
2-Amino-5-phosphonovalerate - pharmacology
Acids
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology
AMPA antagonists
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - physiopathology
Animals
Antibodies
Autoradiography
Blotting, Western
Drug dosages
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
glutamate receptors
Laboratory animals
Male
Mice
Mice, Mutant Strains
Motor Neurons - chemistry
Motor Neurons - pathology
Motor Neurons - physiology
NBQX
Nerve Degeneration - physiopathology
Neurons
Neurotoxins - metabolism
Quinoxalines - pharmacology
Receptors, AMPA - analysis
Receptors, AMPA - immunology
Receptors, AMPA - physiology
Spinal cord
Spinal Cord - chemistry
Spinal Cord - cytology
Tritium
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Summary:We studied ionotropic glutamate receptor subtypes and the effect of chronic treatment with NBQX [6‐nitro‐7‐sulphamoyl‐benzo(F)quinoxaline‐2,3‐dione], a selective (rs)‐α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptor antagonist, in the spinal cord of mnd mice. NBQX (8 mg/kg daily i.p. for 3 weeks starting from 24 weeks old) significantly improved the behavioural scores (hind leg extension reflex, cage rung grasping and gait) in mnd mice, measured after the last drug injection, and increased the number of mice with ‘normal’ gait (from 50% to 90%, P
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.1999.00588.x