N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation

Background and purpose The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), wit...

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Bibliographic Details
Published in:European journal of neurology 2014-04, Vol.21 (4), p.679-683
Main Authors: Purroy, F., Suárez-Luis, I., Mauri-Capdevila, G., Cambray, S., Farré, J., Sanahuja, J., Piñol-Ripoll, G., Quílez, A., González-Mingot, C., Begué, R., Gil, M. I., Fernández, E., Benabdelhak, I.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
atrial fibrillation
Atrial Fibrillation - blood
Atrial Fibrillation - complications
biomarker
C-Reactive Protein - metabolism
cardioembolic
Cytokines - blood
Female
Humans
Ischemic Attack, Transient - blood
Ischemic Attack, Transient - complications
Male
Middle Aged
Natriuretic Peptide, Brain - blood
NT-proBNP
Peptide Fragments - blood
Phosphopyruvate Hydratase - blood
Retrospective Studies
Risk Factors
Time Factors
transient ischemic attack
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Summary:Background and purpose The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum biomarkers measured in consecutive TIA patients. Methods The concentrations of interleukin‐6 (IL‐6), tumor necrosis factor‐alpha, neuron‐specific enolase, high‐sensitivity C‐reactive protein, IL‐1‐α and the N‐terminal pro‐B type natriuretic peptide (NT‐proBNP) were quantified in the serum of 140 patients with TIA and 44 non‐stroke subjects. Measurements were performed at different times throughout evolution: within 24 h of symptoms onset and at days 7 and 90. Results With the exception of IL‐6, all biomarkers were higher in TIA patients than in controls. NT‐proBNP was significantly related to the presence or new diagnosis of AF at all time points analyzed. Furthermore, the baseline NT‐proBNP level was significantly higher than values at the 7‐day and 90‐day follow‐up. For this reason, different cut‐off values were obtained at different times: 313 pg/ml at baseline [odds ratio (OR) = 18.99, P 
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.12222