PO-0147aEfficiency Of The Combined Antiviral Therapy Of Chronic Hepatitis C In Children

AimThe purpose of this work was to study efficiency of the combined antiviral therapy in children with chronic hepatitis C in Republic of Moldova.MethodsIn compliance with the National Program (2007-2016) in paediatric hepatology department 35 children, aged 4-17 years, were treated with pegylated i...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A296-A296
Main Authors: Raba, T, Sciuca, S
Format: Article
Language:English
Subjects:
Hepatitis C virus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AimThe purpose of this work was to study efficiency of the combined antiviral therapy in children with chronic hepatitis C in Republic of Moldova.MethodsIn compliance with the National Program (2007-2016) in paediatric hepatology department 35 children, aged 4-17 years, were treated with pegylated interferon alpha 2b (60 mcg/m2/week) plus ribavirin in a dose of 15 mg/kg/day; therapy length of 24 weeks for genotype 2 and 3 or 48 weeks for genotype 1b. The diagnosis was confirmed by clinical, biochemical, immunological modification, including degree of viremia (ARN VHC PCR Real Time ROTOR Gene6000 CORBETT RESEARCH) and transient elastometry (Fibroscan) for detecting liver fibrosis.ResultsChronic hepatitis C (genotype 1b - 31, genotype 2-1, genotype 3a in 3 children) was characterised by the minimal clinical signs, low biochemical activity in 60% of cases. Low virus loading (
ISSN:0003-9888
DOI:10.1136/archdischild-2014-307384.811