NT-28 NEUROPROTECTIVE EFFECTS OF BACOPA MONNIERI AND ROSMARINUS OFFICINALIS SUPERCRITICAL CO2 EXTRACTS

Ethnobotanical evidence suggests that herbs such as brahmi (Bacopa monnieri) and rosemary (Rosmarinus officinalis) may possess anti-oxidant and neuroprotective properties. We compared the anti-oxidant and neuroprotective effects of supercritical extract of Bacopa monnieri (BM) and rosemary anti-oxid...

Full description

Saved in:
Bibliographic Details
Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2014-11, Vol.16 (suppl 5), p.v164-v164
Main Authors: Ramachandran, C., Quirin, K.-W., Escalon, E., Melnick, S.
Format: Article
Language:English
Subjects:
Bacopa monnieri
Rosmarinus officinalis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ethnobotanical evidence suggests that herbs such as brahmi (Bacopa monnieri) and rosemary (Rosmarinus officinalis) may possess anti-oxidant and neuroprotective properties. We compared the anti-oxidant and neuroprotective effects of supercritical extract of Bacopa monnieri (BM) and rosemary anti-oxidant (RA) extract obtained from Rosmarinus officinalis as well as their combination to examine the effects on human glial (U-87 MG) and embryonic mouse hypothalamus (EMH) cells. BM, RA and their combination (1:1) are not cytotoxic in both glial and EMH cell lines up to 200 mu g/ml concentration. BM + RA combination has better anti-oxidant potential and anti-lipid peroxidation activity than either agent alone. Although BM + RA showed almost similar inhibition of phospho tau expression as BM or RA alone, the combination has better inhibitory effect on Amyloid Precursor Protein (APP) synthesis and higher brain-derived neurotrophic factor (BDNF) production in hypothalamus cells than single agents. These results suggest that BM + RA is more neuroprotective than BM or RA individually.
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/nou265.26