Effect of End-Stage Renal Disease on Rate of Progression of Aortic Stenosis

This study aimed to investigate the progression of mild-to-moderate aortic stenosis (AS) in patients with end-stage renal disease (ESRD) and determine its metabolic and hemodynamic contributors and clinical outcomes. A total of 74 patients with ESRD (50 men, age 72 ± 11 years) with mild-to-moderate...

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Bibliographic Details
Published in:The American journal of cardiology 2016-06, Vol.117 (12), p.1972-1977
Main Authors: Kim, Darae, MD, Shim, Chi Young, MD, PhD, Hong, Geu-Ru, MD, PhD, Cho, In Jeong, MD, Chang, Hyuk-Jae, MD, PhD, Ha, Jong-Won, MD, PhD, Chung, Namsik, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - diagnosis
Aortic Valve Stenosis - physiopathology
Calcification
Cardiovascular
Cholesterol
Disease Progression
Echocardiography, Doppler
Echocardiography, Transesophageal
Electrocardiography
Female
Follow-Up Studies
Heart failure
Heart surgery
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Kidney diseases
Kidney Failure, Chronic - complications
Male
Prognosis
Retrospective Studies
Stroke
Stroke Volume - physiology
Velocity
Ventricular Function, Left - physiology
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Summary:This study aimed to investigate the progression of mild-to-moderate aortic stenosis (AS) in patients with end-stage renal disease (ESRD) and determine its metabolic and hemodynamic contributors and clinical outcomes. A total of 74 patients with ESRD (50 men, age 72 ± 11 years) with mild-to-moderate AS were compared with 79 age- and gender-matched controls with normal kidney function. Clinical, laboratory, and echocardiographic features and clinical outcomes including aortic valve (AV) intervention, hospitalization due to heart failure, and cardiovascular death were analyzed. Patients with ESRD were divided into 2 subgroups according to their rate of AV area changes (group 1 [n = 28], rapid progression; and group 2 [n = 46], slow progression). Progression in the degree of AS was noted in 38% of patients with ESRD and 18% of controls (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.03.048