super(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the super(1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophreni...

Full description

Saved in:
Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2016-05, Vol.468 (1), p.168-172
Main Authors: Menschikov, P E, Semenova, NA, Ublinskiy, M V, Akhadov, T A, Keshishyan, R A, Lebedeva, I S, Omelchenko, MA, Kaleda, V G, Varfolomeev, S D
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the super(1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672916030029