Local administration of resveratrol inhibits excitability of nociceptive wide-dynamic range neurons in rat trigeminal spinal nucleus caudalis

Highlights • Local resveratrol injection suppresses nociceptive SpVc WDR neuronal excitability. • Neuronal firing rates were dose-dependently inhibited by resveratrol. • The inhibitory effect of resveratrol lasted for 20 min and was reversible. • The potency of inhibition by resveratrol almost equal...

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Bibliographic Details
Published in:Brain research bulletin 2016-06, Vol.124, p.262-268
Main Authors: Shimazu, Yoshihito, Shibuya, Eri, Takehana, Shiori, Sekiguchi, Kenta, Oshima, Katsuo, Kamata, Hiroaki, Karibe, Hiroyuki, Takeda, Mamoru
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Analysis of Variance
Anesthetics, Local - therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Complementary and alternative medicine
Dose-Response Relationship, Drug
Extracellular single-unit recording
Injections, Subcutaneous
Lidocaine
Lidocaine - therapeutic use
Local anesthetic agents
Male
Neurology
Nociception
Nociception - drug effects
Nociceptive Pain - drug therapy
Nociceptive Pain - etiology
Nociceptors - drug effects
Physical Stimulation - adverse effects
Rats
Rats, Wistar
Resveratrol
Stilbenes - pharmacology
Trigeminal Nucleus, Spinal - cytology
Trigeminal spinal nucleus caudalis
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Summary:Highlights • Local resveratrol injection suppresses nociceptive SpVc WDR neuronal excitability. • Neuronal firing rates were dose-dependently inhibited by resveratrol. • The inhibitory effect of resveratrol lasted for 20 min and was reversible. • The potency of inhibition by resveratrol almost equaled that of 1% lidocaine. • Resveratrol may be an effective treatment option for trigeminal pain.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.06.001